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Title: Empowering frail older adults: multicomponent elastic-band exercises and BCAA supplementation unleash physical health and preserve haematological biomarkers
Authors: Caldo, Adriana 
Furtado, Guilherme E. 
Chupel, Matheus U. 
Letieri, Rubens Vinícius 
Neves, Rafael Santos 
Direto, Fábio
Barros, Marcelo P.
Bachi, André L. L.
Matheu, Ander
Martins, Faber
Massart, Alain 
Teixeira, Ana Maria 
Keywords: cardiovascular risk; frail older adults; blood markers; sarcopenia; platelets; Sustainable Development Goals 3
Issue Date: 2023
Publisher: Frontiers Media S.A.
Project: MPB was supported by São Paulo Research Foundation (FAPESP, grant no 2017/06032-2), and National Council of Scientific and Technology Development (CNPq: PQ-2 #311839/ 2021-5, Brazil). AB was supported by São Paulo Research Foundation (FAPESP, grants no 10/50025-1, 2016/04845-3, and 2019/14115-0), and National Council of Scientific and Technology Development (CNPq, grant no 307674/2017-7. “Guilherme Furtado” thanks the National funding by FCT- Foundation for Science and Technology, P.I., through the institutional scientific employment program-contract (CEECINST/00077/2021) 
Serial title, monograph or event: Frontiers in Sports and Active Living
Volume: 5
Abstract: The effectiveness of Branched Chain Amino Acids (BCAAs) supplementation on enhancing exercise performance in both young and older adults remains a topic of debate. Recent research suggests that BCAAs combined with regular exercise might have an impact on human erythropoiesis, blood dynamics, and iron homeostasis. Given the increasing longevity of the global population, it is crucial to investigate the potential benefits of BCAA supplementation and regular exercise as non-pharmacological interventions for improving the overall health of frail older adults. To assess the influence of a 40-week multicomponent exercise intervention (MEP) combined BCCA supplementation on the haematological indicators of frail older adults (83-93 years old) residing in nursing homes. A prospective, naturalistic, controlled clinical trial employing an intervention-washout-intervention was conducted for this purpose. The study included four experimental groups: MEP plus BCAA supplementation (MEP + BCAA, n = 8), MEP only (n = 7), BCAA supplementation only (n = 7), and control group non exercising (CG, n = 13). Fried's physical frailty (PF) protocol was employed to stratify the participants. Additionally, the assessment included the evaluation of nutritional status, comorbidities, and anthropometric measurements. Among the several haematological markers examined, only mean cellular Haemoglobin Concentration (MCH) [F = 4.09; p < 0.03] and Mean Cell haemoglobin Concentration (MCHC) [F = 10, 323; p < 0,0001] showed significant effects of time group. Our findings demonstrate that a long-term intervention with BCAA plus MEP did not lead to significant alterations in the haematological profile. An 8-week withdrawal from interventions did not affect the frailty status in the MEP and MEP + BCAA groups, whereas the control group exhibited an increase in PF status. The findings, demonstrating the potential pro-immune effect and maintenance of MCH and MCHC levels, highlight the relevance of incorporating exercise and nutritional strategies to promote healthy aging. This study contributes to the achievement of the United Nations Sustainable Development Goals 3 (good health and well-being) and 10 (reduced Inequalities) for all.
ISSN: 2624-9367
DOI: 10.3389/fspor.2023.1171220
Rights: openAccess
Appears in Collections:I&D CIDAF - Artigos em Revistas Internacionais
FCDEF - Artigos em Revistas Internacionais

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