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https://hdl.handle.net/10316/114147
Title: | Development of an innovative flexible paper-based methanol fuel cell (PB-DMFC) sensing platform – Application to sarcosine detection | Authors: | Carneiro, Liliana P.T. Pinto, Alexandra M.F.R. Sales, M. Goreti F. |
Keywords: | Paper-based methanol fuel cell; Sensing platform; Molecularly imprinted polymer; Sarcosine; Point of care; Cancer biomarker | Issue Date: | 2023 | Publisher: | Elsevier | Project: | SFRH/ BD/122954/2016 COVID/BD/151738/2021 LA/P/0045/2020 UIDB/00532/2020 UIDP/00532/2020 |
Serial title, monograph or event: | Chemical Engineering Journal | Volume: | 452 | Abstract: | This work describes for the first time a paper-based direct methanol fuel cell platform (PB-DMFC) that functions as an energy source and biosensor, assembled on a simple paper substrate for point-of-care (POC) applications, targeting sarcosine as proof-of-concept. Specifically, a methanol fuel cell strip was developed from a square of Whatman paper, acting as substrate. The paper strip was treated with an impermeable agent (paraffin solution) and supported all fuel cell device components, including the electrolyte (Nafion®), anode electrode (carbon black Pt/Ru), cathode electrode (carbon black Pt), and current collectors (silver edges). All the described components formed a flexible single layer that operated in a completely passive mode by adding few microliters of a methanol solution on the anode side and by using atmospheric oxygen on the cathode side. The obtained platform had a stable electrical signal with an average OCV value of 0.45–0.55 V and a maximum power density of 20–50 μW/cm2, depending on the methanol concentration used (0.5 M–2 M). A sensing layer was built in situ on the anode electrode by electropolymerization of a solution of 3,4-ethylenedioxythiophene (EDOT) and pyrrole (Py) as monomers. The obtained PB-DMFC/biosensor was calibrated at room temperature in buffer and healthy human urine and showed linear responses from 1.0 × 10 7 to 1.0 × 10 3 M with a detection limit of 6.6 × 10 8 M. Selectivity studies evidenced signals changing within 1–10%, both in positive and negative directions. Results evidenced good reproducibility. Overall, the obtained results demonstrate a self-sufficient biosensor for the detection of sarcosine consisting of an innovative paper-based methanol fuel cell strip. This concept can open new horizons for massification of biosensors even in places with energy shortage. | URI: | https://hdl.handle.net/10316/114147 | ISSN: | 13858947 | DOI: | 10.1016/j.cej.2022.139563 | Rights: | openAccess |
Appears in Collections: | FCTUC Eng.Química - Artigos em Revistas Internacionais |
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Development of an innovative flexible paper-based methanol fuel cell (PB-DMFC) sensing platform – Application to sarcosine detection.pdf | 7.42 MB | Adobe PDF | View/Open |
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