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https://hdl.handle.net/10316/113971
Title: | A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line | Authors: | Silva, Jéssica D. Marques, Joana Santos, Inês P. Carvalho, Ana L. M. Batista de Martins, Clara B. Laginha, Raquel Batista de Carvalho, Luís A. E. Marques, M. P.aula M. |
Keywords: | anticancer; platinum complexes; polyamines; A549 lung cancer; microRaman; microFTIR | Issue Date: | 10-Feb-2023 | Publisher: | MDPI | Project: | UIDB/ 00070/2020 UIDP/00070/2020 |
Serial title, monograph or event: | Molecules | Volume: | 28 | Issue: | 4 | Abstract: | A dinuclear Pt(II) complex with putrescine as bridging polyamine ligand ([Pt2Put2(NH3)4]Cl4) was synthesized and assessed as to its potential anticancer activity against a human non-small cell lung cancer line (A549), as well as towards non-cancer cells (BEAS-2B). This effect was evaluated through in vitro cytotoxicity assays (MTT and SRB) coupled to microFTIR and microRaman spectroscopies, the former delivering information on growth-inhibiting and cytotoxic abilities while the latter provided very specific information on the metabolic impact of the metal agent (at the sub-cellular level). Regarding cancer cells, a major impact of [Pt2Put2(NH3)4]Cl4 was evidenced on cellular proteins and lipids, as compared to DNA, particularly via the Amide I and Amide II signals. The effect of the chelate on non-malignant cells was lower than on malignant ones, evidencing a promising low toxicity towards healthy cells. | URI: | https://hdl.handle.net/10316/113971 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules28041698 | Rights: | openAccess |
Appears in Collections: | I&D QFM-UC - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais FCTUC Química - Artigos em Revistas Internacionais |
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