Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/113971
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Silva, Jéssica D. | - |
dc.contributor.author | Marques, Joana | - |
dc.contributor.author | Santos, Inês P. | - |
dc.contributor.author | Carvalho, Ana L. M. Batista de | - |
dc.contributor.author | Martins, Clara B. | - |
dc.contributor.author | Laginha, Raquel | - |
dc.contributor.author | Batista de Carvalho, Luís A. E. | - |
dc.contributor.author | Marques, M. P.aula M. | - |
dc.date.accessioned | 2024-03-13T10:45:30Z | - |
dc.date.available | 2024-03-13T10:45:30Z | - |
dc.date.issued | 2023-02-10 | - |
dc.identifier.issn | 1420-3049 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/113971 | - |
dc.description.abstract | A dinuclear Pt(II) complex with putrescine as bridging polyamine ligand ([Pt2Put2(NH3)4]Cl4) was synthesized and assessed as to its potential anticancer activity against a human non-small cell lung cancer line (A549), as well as towards non-cancer cells (BEAS-2B). This effect was evaluated through in vitro cytotoxicity assays (MTT and SRB) coupled to microFTIR and microRaman spectroscopies, the former delivering information on growth-inhibiting and cytotoxic abilities while the latter provided very specific information on the metabolic impact of the metal agent (at the sub-cellular level). Regarding cancer cells, a major impact of [Pt2Put2(NH3)4]Cl4 was evidenced on cellular proteins and lipids, as compared to DNA, particularly via the Amide I and Amide II signals. The effect of the chelate on non-malignant cells was lower than on malignant ones, evidencing a promising low toxicity towards healthy cells. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | UIDB/ 00070/2020 | pt |
dc.relation | UIDP/00070/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | anticancer | pt |
dc.subject | platinum complexes | pt |
dc.subject | polyamines | pt |
dc.subject | A549 lung cancer | pt |
dc.subject | microRaman | pt |
dc.subject | microFTIR | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Platinum | pt |
dc.subject.mesh | Cell Line, Tumor | pt |
dc.subject.mesh | Carcinoma, Non-Small-Cell Lung | pt |
dc.subject.mesh | Lung Neoplasms | pt |
dc.subject.mesh | Antineoplastic Agents | pt |
dc.title | A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line | pt |
dc.type | article | - |
degois.publication.firstPage | 1698 | pt |
degois.publication.issue | 4 | pt |
degois.publication.title | Molecules | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/molecules28041698 | pt |
degois.publication.volume | 28 | pt |
dc.date.embargo | 2023-02-10 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | Molecular Physical-Chemistry R&D Unit | - |
crisitem.project.grantno | Molecular Physical-Chemistry R&D Unit | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | QFM-UC – Molecular Physical-Chemistry R&D Unit | - |
crisitem.author.researchunit | QFM-UC – Molecular Physical-Chemistry R&D Unit | - |
crisitem.author.orcid | 0000-0001-9305-4865 | - |
crisitem.author.orcid | 0000-0002-7333-9158 | - |
crisitem.author.orcid | 0000-0003-2463-246X | - |
crisitem.author.orcid | 0000-0003-1280-3321 | - |
crisitem.author.orcid | 0000-0002-2188-4015 | - |
crisitem.author.orcid | 0000-0002-8391-0055 | - |
Appears in Collections: | I&D QFM-UC - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais FCTUC Química - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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A-NonConventional-Platinum-Drug-against-a-NonSmall-Cell-Lung-Cancer-LineMolecules.pdf | 2.08 MB | Adobe PDF | View/Open |
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