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https://hdl.handle.net/10316/113942
Title: | Natural Killer T-like Cells: Immunobiology and Role in Disease | Authors: | Almeida, Jani-Sofia Casanova, José M. Santos-Rosa, Manuel Tarazona, Raquel Solana, Rafael Rodrigues-Santos, Paulo |
Keywords: | natural killer T-like cells; innate-like cells; ageing; inflammation; infection; pregnancy; transplantation; autoimmunity; neurological disorders; cancer | Issue Date: | 1-Feb-2023 | Publisher: | MDPI | Project: | POCI-01-0145-FEDER-007440 UIDB/04539/ 2020 UIDP/04539/2020 LA/P/0058/2020 |
Serial title, monograph or event: | International Journal of Molecular Sciences | Volume: | 24 | Issue: | 3 | Abstract: | CD56+ T cells are generally recognized as a distinct population of T cells and are categorized as NKT-like cells. Although our understanding of NKT-like cells is far from satisfactory, it has been shown that aging and a number of disease situations have impacted these cells. To construct an overview of what is currently known, we reviewed the literature on human NKT-like cells. NKT-like cells are highly differentiated T cells with "CD1d-independent" antigen recognition and MHC-unrestricted cell killing. The genesis of NKT-like cells is unclear; however, it is proposed that the acquisition of innate characteristics by T cells could represent a remodeling process leading to successful aging. Additionally, it has been shown that NKT-like cells may play a significant role in several pathological conditions, making it necessary to comprehend whether these cells might function as prognostic markers. The quantification and characterization of these cells might serve as a cutting-edge indicator of individual immune health. Additionally, exploring the mechanisms that can control their killing activity in different contexts may therefore result in innovative therapeutic alternatives in a wide range of disease settings. | URI: | https://hdl.handle.net/10316/113942 | ISSN: | 1422-0067 | DOI: | 10.3390/ijms24032743 | Rights: | openAccess |
Appears in Collections: | I&D CIBB - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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