Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/113942
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Almeida, Jani-Sofia | - |
dc.contributor.author | Casanova, José M. | - |
dc.contributor.author | Santos-Rosa, Manuel | - |
dc.contributor.author | Tarazona, Raquel | - |
dc.contributor.author | Solana, Rafael | - |
dc.contributor.author | Rodrigues-Santos, Paulo | - |
dc.date.accessioned | 2024-03-12T09:55:46Z | - |
dc.date.available | 2024-03-12T09:55:46Z | - |
dc.date.issued | 2023-02-01 | - |
dc.identifier.issn | 1422-0067 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/113942 | - |
dc.description.abstract | CD56+ T cells are generally recognized as a distinct population of T cells and are categorized as NKT-like cells. Although our understanding of NKT-like cells is far from satisfactory, it has been shown that aging and a number of disease situations have impacted these cells. To construct an overview of what is currently known, we reviewed the literature on human NKT-like cells. NKT-like cells are highly differentiated T cells with "CD1d-independent" antigen recognition and MHC-unrestricted cell killing. The genesis of NKT-like cells is unclear; however, it is proposed that the acquisition of innate characteristics by T cells could represent a remodeling process leading to successful aging. Additionally, it has been shown that NKT-like cells may play a significant role in several pathological conditions, making it necessary to comprehend whether these cells might function as prognostic markers. The quantification and characterization of these cells might serve as a cutting-edge indicator of individual immune health. Additionally, exploring the mechanisms that can control their killing activity in different contexts may therefore result in innovative therapeutic alternatives in a wide range of disease settings. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | POCI-01-0145-FEDER-007440 | pt |
dc.relation | UIDB/04539/ 2020 | pt |
dc.relation | UIDP/04539/2020 | pt |
dc.relation | LA/P/0058/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | natural killer T-like cells | pt |
dc.subject | innate-like cells | pt |
dc.subject | ageing | pt |
dc.subject | inflammation | pt |
dc.subject | infection | pt |
dc.subject | pregnancy | pt |
dc.subject | transplantation | pt |
dc.subject | autoimmunity | pt |
dc.subject | neurological disorders | pt |
dc.subject | cancer | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Antigens, CD1d | pt |
dc.subject.mesh | Killer Cells, Natural | pt |
dc.subject.mesh | Aging | pt |
dc.subject.mesh | Natural Killer T-Cells | pt |
dc.title | Natural Killer T-like Cells: Immunobiology and Role in Disease | pt |
dc.type | article | - |
degois.publication.firstPage | 2743 | pt |
degois.publication.issue | 3 | pt |
degois.publication.title | International Journal of Molecular Sciences | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/ijms24032743 | pt |
degois.publication.volume | 24 | pt |
dc.date.embargo | 2023-02-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - CIBB | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - Associate Laboratory | - |
crisitem.author.orcid | 0000-0002-0561-0364 | - |
crisitem.author.orcid | 0000-0003-0789-8637 | - |
Appears in Collections: | I&D CIBB - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Natural-Killer-Tlike-Cells-Immunobiology-and-Role-in-DiseaseInternational-Journal-of-Molecular-Sciences.pdf | 1.63 MB | Adobe PDF | View/Open |
Page view(s)
81
checked on Oct 16, 2024
Download(s)
35
checked on Oct 16, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License