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Title: Phase-Resolved Optical Coherence Elastography: An Insight into Tissue Displacement Estimation
Authors: Batista, Ana 
Serranho, Pedro 
Santos, Mário 
Correia, Carlos 
Domingues, José P. 
Loureiro, Custódio 
Cardoso, João Manuel 
Barbeiro, Sílvia 
Morgado, Miguel 
Bernardes, Rui 
Keywords: optical coherence elastography; phase-resolved OCE; displacement estimation; Young’s modulus
Issue Date: 13-Apr-2023
Publisher: MDPI
Project: UIDB/4950/2020 
Serial title, monograph or event: Sensors
Volume: 23
Issue: 8
Abstract: Robust methods to compute tissue displacements in optical coherence elastography (OCE) data are paramount, as they play a significant role in the accuracy of tissue elastic properties estimation. In this study, the accuracy of different phase estimators was evaluated on simulated OCE data, where the displacements can be accurately set, and on real data. Displacement (∆d) estimates were computed from (i) the original interferogram data (Δφori) and two phase-invariant mathematical manipulations of the interferogram: (ii) its first-order derivative (Δφd) and (iii) its integral (Δφint). We observed a dependence of the phase difference estimation accuracy on the initial depth location of the scatterer and the magnitude of the tissue displacement. However, by combining the three phase-difference estimates (Δdav), the error in phase difference estimation could be minimized. By using Δdav, the median root-mean-square error associated with displacement prediction in simulated OCE data was reduced by 85% and 70% in data with and without noise, respectively, in relation to the traditional estimate. Furthermore, a modest improvement in the minimum detectable displacement in real OCE data was also observed, particularly in data with low signal-to-noise ratios. The feasibility of using Δdav to estimate agarose phantoms' Young's modulus is illustrated.
ISSN: 1424-8220
DOI: 10.3390/s23083974
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
FCTUC Matemática - Artigos em Revistas Internacionais
FCTUC Eng.Electrotécnica - Artigos em Revistas Internacionais
FCTUC Física - Artigos em Revistas Internacionais
I&D CIBIT - Artigos em Revistas Internacionais

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