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https://hdl.handle.net/10316/113589
Title: | Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia | Authors: | Whiteside, David J. Malpetti, Maura Jones, P Simon Ghosh, Boyd C. P. Coyle-Gilchrist, Ian van Swieten, John C. Seelaar, Harro Jiskoot, Lize Borroni, Barbara Sánchez-Valle, Raquel Moreno, Fermin Laforce, Robert Graff, Caroline Synofzik, Matthis Galimberti, Daniela Masellis, Mario Tartaglia, Maria Carmela Finger, Elizabeth Vandenberghe, Rik de Mendonça, Alexandre Tagliavini, Fabrizio Butler, Chris R. Santana, Isabel Ber, Isabelle Le Gerhard, Alexander Ducharme, Simon Levin, Johannes Danek, Adrian Otto, Markus Sorbi, Sandro Pasquier, Florence Bouzigues, Arabella Russell, Lucy L. Rohrer, Jonathan D. Rowe, James B. Rittman, Timothy |
Keywords: | disease progression; frontotemporal dementia; functional magnetic resonance imaging (fMRI); network dynamics; presymptomatic | Issue Date: | May-2023 | Publisher: | Wiley-Blackwell | Project: | Medical Research Council UK, Grant/Award Numbers: MR/M023664/1, SUAG/092116768; JPND GENFI-PROX, Grant/Award Number: DLR/BMBF 2019-02248; Munich Cluster for Systems Neurology, Grant/Award Number: 390857198; National Institute for Health Research (NIHR) Biomedical Research Centre at Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge, Grant/Award Number: BRC-1215-20014; Cambridge Centre for Parkinson-plus, Grant/Award Number: RG95450;Wellcome Trust, Grant/Award Number: 220258 | Serial title, monograph or event: | Alzheimer's and Dementia | Volume: | 19 | Issue: | 5 | Abstract: | Introduction: We tested whether changes in functional networks predict cognitive decline and conversion from the presymptomatic prodrome to symptomatic disease in familial frontotemporal dementia (FTD). Methods: For hypothesis generation, 36 participants with behavioral variant FTD (bvFTD) and 34 controls were recruited from one site. For hypothesis testing, we studied 198 symptomatic FTD mutation carriers, 341 presymptomatic mutation carriers, and 329 family members without mutations. We compared functional network dynamics between groups, with clinical severity and with longitudinal clinical progression. Results: We identified a characteristic pattern of dynamic network changes in FTD, which correlated with neuropsychological impairment. Among presymptomatic mutation carriers, this pattern of network dynamics was found to a greater extent in those who subsequently converted to the symptomatic phase. Baseline network dynamic changes predicted future cognitive decline in symptomatic participants and older presymptomatic participants. Discussion: Dynamic network abnormalities in FTD predict cognitive decline and symptomatic conversion. | URI: | https://hdl.handle.net/10316/113589 | ISSN: | 1552-5260 1552-5279 |
DOI: | 10.1002/alz.12824 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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Alzheimer s Dementia - 2022 - Whiteside - Temporal dynamics predict symptom onset and cognitive decline in familial.pdf | 1.35 MB | Adobe PDF | View/Open |
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