Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/113589
DC Field | Value | Language |
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dc.contributor.author | Whiteside, David J. | - |
dc.contributor.author | Malpetti, Maura | - |
dc.contributor.author | Jones, P Simon | - |
dc.contributor.author | Ghosh, Boyd C. P. | - |
dc.contributor.author | Coyle-Gilchrist, Ian | - |
dc.contributor.author | van Swieten, John C. | - |
dc.contributor.author | Seelaar, Harro | - |
dc.contributor.author | Jiskoot, Lize | - |
dc.contributor.author | Borroni, Barbara | - |
dc.contributor.author | Sánchez-Valle, Raquel | - |
dc.contributor.author | Moreno, Fermin | - |
dc.contributor.author | Laforce, Robert | - |
dc.contributor.author | Graff, Caroline | - |
dc.contributor.author | Synofzik, Matthis | - |
dc.contributor.author | Galimberti, Daniela | - |
dc.contributor.author | Masellis, Mario | - |
dc.contributor.author | Tartaglia, Maria Carmela | - |
dc.contributor.author | Finger, Elizabeth | - |
dc.contributor.author | Vandenberghe, Rik | - |
dc.contributor.author | de Mendonça, Alexandre | - |
dc.contributor.author | Tagliavini, Fabrizio | - |
dc.contributor.author | Butler, Chris R. | - |
dc.contributor.author | Santana, Isabel | - |
dc.contributor.author | Ber, Isabelle Le | - |
dc.contributor.author | Gerhard, Alexander | - |
dc.contributor.author | Ducharme, Simon | - |
dc.contributor.author | Levin, Johannes | - |
dc.contributor.author | Danek, Adrian | - |
dc.contributor.author | Otto, Markus | - |
dc.contributor.author | Sorbi, Sandro | - |
dc.contributor.author | Pasquier, Florence | - |
dc.contributor.author | Bouzigues, Arabella | - |
dc.contributor.author | Russell, Lucy L. | - |
dc.contributor.author | Rohrer, Jonathan D. | - |
dc.contributor.author | Rowe, James B. | - |
dc.contributor.author | Rittman, Timothy | - |
dc.date.accessioned | 2024-02-22T12:22:58Z | - |
dc.date.available | 2024-02-22T12:22:58Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 1552-5260 | pt |
dc.identifier.issn | 1552-5279 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/113589 | - |
dc.description.abstract | Introduction: We tested whether changes in functional networks predict cognitive decline and conversion from the presymptomatic prodrome to symptomatic disease in familial frontotemporal dementia (FTD). Methods: For hypothesis generation, 36 participants with behavioral variant FTD (bvFTD) and 34 controls were recruited from one site. For hypothesis testing, we studied 198 symptomatic FTD mutation carriers, 341 presymptomatic mutation carriers, and 329 family members without mutations. We compared functional network dynamics between groups, with clinical severity and with longitudinal clinical progression. Results: We identified a characteristic pattern of dynamic network changes in FTD, which correlated with neuropsychological impairment. Among presymptomatic mutation carriers, this pattern of network dynamics was found to a greater extent in those who subsequently converted to the symptomatic phase. Baseline network dynamic changes predicted future cognitive decline in symptomatic participants and older presymptomatic participants. Discussion: Dynamic network abnormalities in FTD predict cognitive decline and symptomatic conversion. | pt |
dc.language.iso | eng | pt |
dc.publisher | Wiley-Blackwell | pt |
dc.relation | Medical Research Council UK, Grant/Award Numbers: MR/M023664/1, SUAG/092116768; JPND GENFI-PROX, Grant/Award Number: DLR/BMBF 2019-02248; Munich Cluster for Systems Neurology, Grant/Award Number: 390857198; National Institute for Health Research (NIHR) Biomedical Research Centre at Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge, Grant/Award Number: BRC-1215-20014; Cambridge Centre for Parkinson-plus, Grant/Award Number: RG95450;Wellcome Trust, Grant/Award Number: 220258 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | disease progression | pt |
dc.subject | frontotemporal dementia | pt |
dc.subject | functional magnetic resonance imaging (fMRI) | pt |
dc.subject | network dynamics | pt |
dc.subject | presymptomatic | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Mutation | pt |
dc.subject.mesh | Brain | pt |
dc.subject.mesh | Magnetic Resonance Imaging | pt |
dc.subject.mesh | Frontotemporal Dementia | pt |
dc.subject.mesh | Cognitive Dysfunction | pt |
dc.title | Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia | pt |
dc.type | article | - |
degois.publication.firstPage | 1947 | pt |
degois.publication.lastPage | 1962 | pt |
degois.publication.issue | 5 | pt |
degois.publication.title | Alzheimer's and Dementia | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1002/alz.12824 | pt |
degois.publication.volume | 19 | pt |
dc.date.embargo | 2023-05-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-8114-9434 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Alzheimer s Dementia - 2022 - Whiteside - Temporal dynamics predict symptom onset and cognitive decline in familial.pdf | 1.35 MB | Adobe PDF | View/Open |
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