Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/113349
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pereira, Patrícia | - |
dc.contributor.author | Neto, Ana S. | - |
dc.contributor.author | Rodrigues, Ana Sofia | - |
dc.contributor.author | Barros, Inês | - |
dc.contributor.author | Miranda, Catarina O. | - |
dc.contributor.author | Santos, João Ramalho | - |
dc.contributor.author | Almeida, Luís Pereira de | - |
dc.contributor.author | Ferreira, José M. F. | - |
dc.contributor.author | Coelho, Jorge | - |
dc.contributor.author | Fonseca, Ana C. | - |
dc.date.accessioned | 2024-02-16T10:39:17Z | - |
dc.date.available | 2024-02-16T10:39:17Z | - |
dc.date.issued | 2023-05-10 | - |
dc.identifier.issn | 2073-4360 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/113349 | - |
dc.description.abstract | This study investigates the osteogenic differentiation of umbilical-cord-derived human mesenchymal stromal cells (hUC-MSCs) on biphasic calcium phosphate (BCP) scaffolds derived from cuttlefish bone doped with metal ions and coated with polymers. First, the in vitro cytocompatibility of the undoped and ion-doped (Sr2+, Mg2+ and/or Zn2+) BCP scaffolds was evaluated for 72 h using Live/Dead staining and viability assays. From these tests, the most promising composition was found to be the BCP scaffold doped with strontium (Sr2+), magnesium (Mg2+) and zinc (Zn2+) (BCP-6Sr2Mg2Zn). Then, samples from the BCP-6Sr2Mg2Zn were coated with poly(ԑ-caprolactone) (PCL) or poly(ester urea) (PEU). The results showed that hUC-MSCs can differentiate into osteoblasts, and hUC-MSCs seeded on the PEU-coated scaffolds proliferated well, adhered to the scaffold surfaces, and enhanced their differentiation capabilities without negative effects on cell proliferation under in vitro conditions. Overall, these results suggest that PEU-coated scaffolds are an alternative to PCL for use in bone regeneration, providing a suitable environment to maximally induce osteogenesis. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | UIDB/50011/2020 | pt |
dc.relation | info:eu-repo/grantAgreement/UIDP/50011/2020 | pt |
dc.relation | LA/P/0006/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | cuttlefish bone | pt |
dc.subject | biphasic calcium phosphate | pt |
dc.subject | polymer coatings | pt |
dc.subject | in vitro cell culture | pt |
dc.subject | osteogenic differentiation | pt |
dc.title | In Vitro Evaluation of Biphasic Calcium Phosphate Scaffolds Derived from Cuttlefish Bone Coated with Poly(ester urea) for Bone Tissue Regeneration | pt |
dc.type | article | - |
degois.publication.firstPage | 2256 | pt |
degois.publication.issue | 10 | pt |
degois.publication.title | Polymers | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/polym15102256 | pt |
degois.publication.volume | 15 | pt |
dc.date.embargo | 2023-05-10 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | CICECO-Aveiro Institute of Materials | - |
crisitem.project.grantno | CICECO-Aveiro Institute of Materials | - |
crisitem.project.grantno | CICECO – Aveiro Institute of Materials | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CIBB - Center for Innovative Biomedicine and Biotechnology | - |
crisitem.author.researchunit | CEMMPRE - Centre for Mechanical Engineering, Materials and Processes | - |
crisitem.author.researchunit | CEMMPRE - Centre for Mechanical Engineering, Materials and Processes | - |
crisitem.author.orcid | 0000-0002-5665-5271 | - |
crisitem.author.orcid | 0000-0001-7060-879X | - |
crisitem.author.orcid | 0000-0002-3893-6416 | - |
crisitem.author.orcid | 0000-0001-5241-8108 | - |
crisitem.author.orcid | 0000-0002-1172-4018 | - |
crisitem.author.orcid | 0000-0001-5831-3307 | - |
crisitem.author.orcid | 0000-0001-9351-1704 | - |
crisitem.author.orcid | 0000-0002-7145-2472 | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais FCTUC Eng.Química - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais I&D CEMMPRE - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
In-Vitro-Evaluation-of-Biphasic-Calcium-Phosphate-Scaffolds-Derived-from-Cuttlefish-Bone-Coated-with-Polyester-urea-for-Bone-Tissue-RegenerationPolymers.pdf | 4.07 MB | Adobe PDF | View/Open |
Page view(s)
81
checked on Oct 16, 2024
Download(s)
26
checked on Oct 16, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License