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Título: | An Overview of Cefiderocol's Therapeutic Potential and Underlying Resistance Mechanisms | Autor: | Domingues, Sara Lima, Tiago Saavedra, Maria José Silva, Gabriela Jorge da |
Palavras-chave: | cephalosporin; carbapenem-resistant; cefiderocol antibacterial activity; cefiderocol resistance; antimicrobial resistance; healthcare infections; siderophore; iron transporter; ESKAPE | Data: | 21-Jun-2023 | Editora: | MDPI | Projeto: | UIDB/04539/2020 UIDP/04539/2020 LA/P/0058/2020. UIDB/AGR/04033/2020 321 (CITAB) UIDB/CVT/00772/2020 (CEVAV) |
Título da revista, periódico, livro ou evento: | Life | Volume: | 13 | Número: | 7 | Resumo: | Antimicrobial resistance continues to increase globally and treatment of difficult-to-treat (DTT) infections, mostly associated with carbapenem-resistant (CR) Pseudomonas aeruginosa, CR Acinetobacter baumannii, and CR- and third-generation-cephalosporins-resistant Enterobacterales remains a challenge for the clinician. The recent approval of cefiderocol has broaden the armamentarium for the treatment of patients with DTT infections. Cefiderocol is a siderophore cephalosporin that has shown excellent antibacterial activity, in part due to its innovative way of cell permeation. It is relatively stable compared to most commonly found carbapenamases. However, some resistant mechanisms to cefiderocol have already been identified and reduced susceptibility has developed during patient treatment, highlighting that the clinical use of cefiderocol must be rational. In this review, we summarize the current available treatments against the former resistant bacteria, and we revise and discuss the mechanism of action of cefiderocol, underlying the biological function of siderophores, the therapeutic potential of cefiderocol, and the mechanisms of resistance reported so far. | URI: | https://hdl.handle.net/10316/112586 | ISSN: | 2075-1729 | DOI: | 10.3390/life13071427 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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An-Overview-of-Cefiderocols-Therapeutic-Potential-and-Underlying-Resistance-MechanismsLife.pdf | 699.15 kB | Adobe PDF | Ver/Abrir |
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