Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/112586
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Domingues, Sara | - |
dc.contributor.author | Lima, Tiago | - |
dc.contributor.author | Saavedra, Maria José | - |
dc.contributor.author | Silva, Gabriela Jorge da | - |
dc.date.accessioned | 2024-02-01T10:59:03Z | - |
dc.date.available | 2024-02-01T10:59:03Z | - |
dc.date.issued | 2023-06-21 | - |
dc.identifier.issn | 2075-1729 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/112586 | - |
dc.description.abstract | Antimicrobial resistance continues to increase globally and treatment of difficult-to-treat (DTT) infections, mostly associated with carbapenem-resistant (CR) Pseudomonas aeruginosa, CR Acinetobacter baumannii, and CR- and third-generation-cephalosporins-resistant Enterobacterales remains a challenge for the clinician. The recent approval of cefiderocol has broaden the armamentarium for the treatment of patients with DTT infections. Cefiderocol is a siderophore cephalosporin that has shown excellent antibacterial activity, in part due to its innovative way of cell permeation. It is relatively stable compared to most commonly found carbapenamases. However, some resistant mechanisms to cefiderocol have already been identified and reduced susceptibility has developed during patient treatment, highlighting that the clinical use of cefiderocol must be rational. In this review, we summarize the current available treatments against the former resistant bacteria, and we revise and discuss the mechanism of action of cefiderocol, underlying the biological function of siderophores, the therapeutic potential of cefiderocol, and the mechanisms of resistance reported so far. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | UIDP/04539/2020 | pt |
dc.relation | LA/P/0058/2020. | pt |
dc.relation | UIDB/AGR/04033/2020 321 (CITAB) | pt |
dc.relation | UIDB/CVT/00772/2020 (CEVAV) | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | cephalosporin | pt |
dc.subject | carbapenem-resistant | pt |
dc.subject | cefiderocol antibacterial activity | pt |
dc.subject | cefiderocol resistance | pt |
dc.subject | antimicrobial resistance | pt |
dc.subject | healthcare infections | pt |
dc.subject | siderophore | pt |
dc.subject | iron transporter | pt |
dc.subject | ESKAPE | pt |
dc.title | An Overview of Cefiderocol's Therapeutic Potential and Underlying Resistance Mechanisms | pt |
dc.type | article | - |
degois.publication.firstPage | 1427 | pt |
degois.publication.issue | 7 | pt |
degois.publication.title | Life | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/life13071427 | pt |
degois.publication.volume | 13 | pt |
dc.date.embargo | 2023-06-21 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-8879-5113 | - |
crisitem.author.orcid | 0000-0002-7479-8540 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
An-Overview-of-Cefiderocols-Therapeutic-Potential-and-Underlying-Resistance-MechanismsLife.pdf | 699.15 kB | Adobe PDF | View/Open |
Page view(s)
39
checked on May 8, 2024
Download(s)
23
checked on May 8, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License