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Title: Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise
Authors: Razi, Omid
Teixeira, Ana M. 
Tartibian, Bakhtyar
Zamani, Nastaran
Knechtle, Beat
Keywords: Multiple sclerosis; COVID-19; Exercise training; Renin–angiotensin system; Respiratory system; Immune system
Issue Date: Jul-2023
Publisher: Springer Nature
Project: Open access funding provided by University of Zurich 
Serial title, monograph or event: Molecular and Cellular Biochemistry
Volume: 478
Issue: 7
Abstract: Coronavirus disease-2019 (COVID-19) is associated with cytokine storm and is characterized by acute respiratory distress syndrome (ARDS) and pneumonia problems. The respiratory system is a place of inappropriate activation of the immune system in people with multiple sclerosis (MS), and this may cause damage to the lung and worsen both MS and infections.The concerns for patients with multiple sclerosis are because of an enhance risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The MS patients pose challenges in this pandemic situation, because of the regulatory defect of autoreactivity of the immune system and neurological and respiratory tract symptoms. In this review, we first indicate respiratory issues associated with both diseases. Then, the main mechanisms inducing lung damages and also impairing the respiratory muscles in individuals with both diseases is discussed. At the end, the leading role of physical exercise on mitigating respiratory issues inducing mechanisms is meticulously evaluated.
ISSN: 0300-8177
DOI: 10.1007/s11010-022-04610-1
Rights: openAccess
Appears in Collections:I&D CIDAF - Artigos em Revistas Internacionais
FCDEF - Artigos em Revistas Internacionais

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