Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/112021
Título: | Functional neuroimaging of responses to multiple sensory stimulations in newborns with perinatal asphyxia | Autor: | Pinto, Carla R. Duarte, João V. Dinis, Alexandra Duarte, Isabel C. Castelhano, João Pinto, Joana Oliveira, Guiomar Castelo-Branco, Miguel |
Palavras-chave: | Newborn; functional magnetic resonance imaging (fMRI); functional near-infrared spectroscopy (fNIRS); perinatal asphyxia (PA); multiple sensory stimulations | Data: | 18-Set-2023 | Editora: | AME Publishing Company | Projeto: | PTDC/DTP-PIC/6032/2014/POCI-01-0145- FEDER-016781 | Título da revista, periódico, livro ou evento: | Translational Pediatrics | Volume: | 12 | Número: | 9 | Resumo: | Background: Functional neuroimaging can provide pathophysiological information in perinatal asphyxia (PA). However, fundamental unresolved questions remain related to the influence of neurovascular coupling (NVC) maturation on functional responses in early development. We aimed to probe the feasibility and compare the responses to multiple sensory stimulations in newborns with PA using functional magnetic resonance imaging (fMRI) and functional near-infrared spectroscopy (fNIRS). Methods: Responses to visual, auditory, and sensorimotor passive stimulation were measured with fMRI and fNIRS and compared in 18 term newborns with PA and six controls. Results: Most newborns exhibited a positive fMRI response during visual and sensorimotor stimulation, higher in the sensorimotor. An asymmetric pattern (negative in the left hemisphere) was observed in auditory stimulation. The fNIRS response most resembling the adult pattern (positive) in PA occurred during auditory stimulation, in which oxyhemoglobin (HbO) increased, and deoxyhemoglobin (HbR) decreased. Significative differences were found in the HbO and HbR profiles in newborns with PA compared to the controls, more evident in auditory stimulation. Positive correlations between the fMRI BOLD signal and at least one fNIRS channel (HbO) in all stimuli in newborns with PA were identified: the strongest was in the auditory (r=0.704) and the weakest in the sensorimotor (r=0.544); in more fNIRS channels, in the visual. Conclusions: Both techniques are feasible physiological assessment tools, suggesting a distinctive level of maturation in sensory and motor areas. Differences in fNIRS profiles in newborns with PA and controls and the fMRI-fNIRS relationship observed can encourage the fNIRS as a clinically emergent valuable tool. | URI: | https://hdl.handle.net/10316/112021 | ISSN: | 2224-4344 | DOI: | 10.21037/tp-23-135 | Direitos: | openAccess |
Aparece nas coleções: | I&D ICNAS - Artigos em Revistas Internacionais I&D CIBIT - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Functional neuroimaging of responses to multiple sensory stimulations in newborns with perinatal asphyxia.pdf | 1.73 MB | Adobe PDF | Ver/Abrir |
Visualizações de página
33
Visto em 8/mai/2024
Downloads
13
Visto em 8/mai/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons