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https://hdl.handle.net/10316/109817
Title: | Emergent biomarkers of residual cardiovascular risk in patients with low HDL-c and/or high triglycerides and average LDL-c concentrations: focus on HDL subpopulations, Oxidized LDL, adiponectin, and uric acid | Authors: | Mascarenhas-Melo, Filipa Palavra, Filipe Marado, Daniela Sereno, José Teixeira-Lemos, Edite Freitas, Isabel Mendonça, Maria Isabel Pinto, Rui Teixeira, Frederico Reis, Flávio |
Issue Date: | 2013 | Publisher: | Hindawi | Project: | SFRH/BD/65483/2009 PEst-C/SAU/UI3282/2011 |
Serial title, monograph or event: | The Scientific World Journal | Volume: | 2013 | Abstract: | This study intended to determine the impact of HDL-c and/or TGs levels on patients with average LDL-c concentration, focusing on lipidic, oxidative, inflammatory, and angiogenic profiles. Patients with cardiovascular risk factors (n = 169) were divided into 4 subgroups, combining normal and low HDL-c with normal and high TGs patients. The following data was analyzed: BP, BMI, waist circumference and serum glucose, Total-c, TGs, LDL-c, oxidized-LDL, total HDL-c and HDL subpopulations, paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF- α , adiponectin, VEGF, and iCAM1. The two populations with increased TGs levels, regardless of the normal or low HDL-c, presented obesity and higher waist circumference, Total-c, LDL-c, Ox-LDL, and uric acid. Adiponectin concentration was significantly lower and VEGF was higher in the population with cumulative low values of HDL-c and high values of TGs, while HDL quality was reduced in the populations with impaired values of HDL-c and/or TGs, viewed by reduced large and increased small HDL subfractions. In conclusion, in a population with cardiovascular risk factors, low HDL-c and/or high TGs concentrations seem to be associated with a poor cardiometabolic profile, despite average LDL-c levels. This condition, often called residual risk, is better evidenced by using both traditional and nontraditional CV biomarkers, including large and small HDL subfractions, Ox-LDL, adiponectin, VEGF, and uric acid. | URI: | https://hdl.handle.net/10316/109817 | ISSN: | 1537-744X | DOI: | 10.1155/2013/387849 | Rights: | openAccess |
Appears in Collections: | I&D IBILI - Artigos em Revistas Internacionais |
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