Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/109817
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mascarenhas-Melo, Filipa | - |
dc.contributor.author | Palavra, Filipe | - |
dc.contributor.author | Marado, Daniela | - |
dc.contributor.author | Sereno, José | - |
dc.contributor.author | Teixeira-Lemos, Edite | - |
dc.contributor.author | Freitas, Isabel | - |
dc.contributor.author | Mendonça, Maria Isabel | - |
dc.contributor.author | Pinto, Rui | - |
dc.contributor.author | Teixeira, Frederico | - |
dc.contributor.author | Reis, Flávio | - |
dc.date.accessioned | 2023-10-30T09:38:16Z | - |
dc.date.available | 2023-10-30T09:38:16Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1537-744X | pt |
dc.identifier.uri | https://hdl.handle.net/10316/109817 | - |
dc.description.abstract | This study intended to determine the impact of HDL-c and/or TGs levels on patients with average LDL-c concentration, focusing on lipidic, oxidative, inflammatory, and angiogenic profiles. Patients with cardiovascular risk factors (n = 169) were divided into 4 subgroups, combining normal and low HDL-c with normal and high TGs patients. The following data was analyzed: BP, BMI, waist circumference and serum glucose, Total-c, TGs, LDL-c, oxidized-LDL, total HDL-c and HDL subpopulations, paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF- α , adiponectin, VEGF, and iCAM1. The two populations with increased TGs levels, regardless of the normal or low HDL-c, presented obesity and higher waist circumference, Total-c, LDL-c, Ox-LDL, and uric acid. Adiponectin concentration was significantly lower and VEGF was higher in the population with cumulative low values of HDL-c and high values of TGs, while HDL quality was reduced in the populations with impaired values of HDL-c and/or TGs, viewed by reduced large and increased small HDL subfractions. In conclusion, in a population with cardiovascular risk factors, low HDL-c and/or high TGs concentrations seem to be associated with a poor cardiometabolic profile, despite average LDL-c levels. This condition, often called residual risk, is better evidenced by using both traditional and nontraditional CV biomarkers, including large and small HDL subfractions, Ox-LDL, adiponectin, VEGF, and uric acid. | pt |
dc.language.iso | eng | pt |
dc.publisher | Hindawi | pt |
dc.relation | SFRH/BD/65483/2009 | pt |
dc.relation | PEst-C/SAU/ UI3282/2011 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Aryldialkylphosphatase | pt |
dc.subject.mesh | Biomarkers | pt |
dc.subject.mesh | Blood Glucose | pt |
dc.subject.mesh | Blood Pressure | pt |
dc.subject.mesh | Body Mass Index | pt |
dc.subject.mesh | Cardiovascular Diseases | pt |
dc.subject.mesh | Cholesterol, HDL | pt |
dc.subject.mesh | Cholesterol, LDL | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Portugal | pt |
dc.subject.mesh | Risk Factors | pt |
dc.subject.mesh | Spectrophotometry | pt |
dc.subject.mesh | Statistics, Nonparametric | pt |
dc.subject.mesh | Triglycerides | pt |
dc.subject.mesh | Waist Circumference | pt |
dc.subject.mesh | Diagnostic Techniques, Cardiovascular | pt |
dc.title | Emergent biomarkers of residual cardiovascular risk in patients with low HDL-c and/or high triglycerides and average LDL-c concentrations: focus on HDL subpopulations, Oxidized LDL, adiponectin, and uric acid | pt |
dc.type | article | - |
degois.publication.firstPage | 387849 | pt |
degois.publication.lastPage | 16 | pt |
degois.publication.title | The Scientific World Journal | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1155/2013/387849 | pt |
degois.publication.volume | 2013 | pt |
dc.date.embargo | 2013-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0003-0786-6280 | - |
crisitem.author.orcid | 0000-0002-6346-8319 | - |
crisitem.author.orcid | 0000-0002-2601-0923 | - |
crisitem.author.orcid | 0000-0003-3401-9554 | - |
Appears in Collections: | I&D IBILI - Artigos em Revistas Internacionais |
Files in This Item:
Page view(s)
58
checked on May 8, 2024
Download(s)
20
checked on May 8, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License