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Title: Impact of splenic artery ligation after major hepatectomy on liver function, regeneration and viability
Authors: Carrapita, Jorge
Abrantes, Ana Margarida 
Campelos, Sofia
Gonçalves, Ana Cristina
Cardoso, Dulce
Ribeiro, Ana Bela Sarmento 
Rocha, Clara 
Santos, Jorge Nunes
Botelho, Maria Filomena 
Tralhão, José Guilherme 
Farges, Olivier
Barbosa, Jorge Maciel
Issue Date: 11-Oct-2016
Publisher: Springer Nature
Project: Strategic Project PEst-C/SAU/UI3282/2013 
Serial title, monograph or event: Scientific Reports
Volume: 6
Issue: 1
Abstract: It was reported that prevention of acute portal overpressure in small-for-size livers by inflow modulation results in a better postoperative outcome. The aim is to investigate the impact of portal blood flow reduction by splenic artery ligation after major hepatectomy in a murine model. Forty-eight rats were subjected to an 85% hepatectomy or 85% hepatectomy and splenic artery ligation. Both groups were evaluated at 24, 48, 72 and 120 post-operative hours: liver function, regeneration and viability. All methods and experiments were carried out in accordance with Coimbra University guidelines. Splenic artery ligation produces viability increase after 24 h, induces a relative decrease in oxidative stress during the first 48 hours, allows antioxidant capacity increment after 24 h, which is reflected in a decrease of half-time normalized liver curve at 48 h and at 72 h and in an increase of mitotic index between 48 h and 72 h. Splenic artery ligation combined with 85% hepatectomy in a murine model, allows portal inflow modulation, promoting an increase in hepatocellular viability and regeneration, without impairing the function, probably by inducing a less marked elevation of oxidative stress at first 48 hours.
ISSN: 2045-2322
DOI: 10.1038/srep34731
Rights: openAccess
Appears in Collections:I&D IBILI - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
I&D INESCC - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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