Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/108917
DC Field | Value | Language |
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dc.contributor.author | Carrapita, Jorge | - |
dc.contributor.author | Abrantes, Ana Margarida | - |
dc.contributor.author | Campelos, Sofia | - |
dc.contributor.author | Gonçalves, Ana Cristina | - |
dc.contributor.author | Cardoso, Dulce | - |
dc.contributor.author | Ribeiro, Ana Bela Sarmento | - |
dc.contributor.author | Rocha, Clara | - |
dc.contributor.author | Santos, Jorge Nunes | - |
dc.contributor.author | Botelho, Maria Filomena | - |
dc.contributor.author | Tralhão, José Guilherme | - |
dc.contributor.author | Farges, Olivier | - |
dc.contributor.author | Barbosa, Jorge Maciel | - |
dc.date.accessioned | 2023-09-25T09:14:47Z | - |
dc.date.available | 2023-09-25T09:14:47Z | - |
dc.date.issued | 2016-10-11 | - |
dc.identifier.issn | 2045-2322 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/108917 | - |
dc.description.abstract | It was reported that prevention of acute portal overpressure in small-for-size livers by inflow modulation results in a better postoperative outcome. The aim is to investigate the impact of portal blood flow reduction by splenic artery ligation after major hepatectomy in a murine model. Forty-eight rats were subjected to an 85% hepatectomy or 85% hepatectomy and splenic artery ligation. Both groups were evaluated at 24, 48, 72 and 120 post-operative hours: liver function, regeneration and viability. All methods and experiments were carried out in accordance with Coimbra University guidelines. Splenic artery ligation produces viability increase after 24 h, induces a relative decrease in oxidative stress during the first 48 hours, allows antioxidant capacity increment after 24 h, which is reflected in a decrease of half-time normalized liver curve at 48 h and at 72 h and in an increase of mitotic index between 48 h and 72 h. Splenic artery ligation combined with 85% hepatectomy in a murine model, allows portal inflow modulation, promoting an increase in hepatocellular viability and regeneration, without impairing the function, probably by inducing a less marked elevation of oxidative stress at first 48 hours. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.relation | Strategic Project PEst-C/SAU/UI3282/2013 | pt |
dc.relation | UID/NEU/04539/2013 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Apoptosis | pt |
dc.subject.mesh | Cell Survival | pt |
dc.subject.mesh | Hepatectomy | pt |
dc.subject.mesh | Hepatocytes | pt |
dc.subject.mesh | Ligation | pt |
dc.subject.mesh | Liver | pt |
dc.subject.mesh | Liver Function Tests | pt |
dc.subject.mesh | Liver Regeneration | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Membrane Potential, Mitochondrial | pt |
dc.subject.mesh | Necrosis | pt |
dc.subject.mesh | Oxidative Stress | pt |
dc.subject.mesh | Primary Cell Culture | pt |
dc.subject.mesh | Rats | pt |
dc.subject.mesh | Rats, Wistar | pt |
dc.subject.mesh | Spleen | pt |
dc.subject.mesh | Splenic Artery | pt |
dc.subject.mesh | Superoxides | pt |
dc.subject.mesh | Survival Analysis | pt |
dc.title | Impact of splenic artery ligation after major hepatectomy on liver function, regeneration and viability | pt |
dc.type | article | - |
degois.publication.firstPage | 34731 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Scientific Reports | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1038/srep34731 | pt |
degois.publication.volume | 6 | pt |
dc.date.embargo | 2016-10-11 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | INESC Coimbra – Institute for Systems Engineering and Computers at Coimbra | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-4185-7871 | - |
crisitem.author.orcid | 0000-0002-4142-4841 | - |
crisitem.author.orcid | 0000-0002-4724-1843 | - |
crisitem.author.orcid | 0000-0001-7202-1650 | - |
Appears in Collections: | I&D IBILI - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais I&D INESCC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Impact-of-splenic-artery-ligation-after-major-hepatectomy-on-liver-function-regeneration-and-viabilityScientific-Reports.pdf | 1.86 MB | Adobe PDF | View/Open |
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