Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/108387
Title: Ultrasensitive gold micro-structured electrodes enabling the detection of extra-cellular long-lasting potentials in astrocytes populations
Authors: Mestre, Ana L. G.
Cerquido, Mónica
Inácio, Pedro M. C.
Asgarifar, Sanaz
Lourenço, Ana S.
Cristiano, Maria L. S.
Aguiar, Paulo
Medeiros, Maria C. R. 
Araújo, Inês M. 
Ventura, João 
Gomes, Henrique L.
Issue Date: 27-Oct-2017
Publisher: Springer Nature
Project: project “Implantable organic devices for advanced therapies” (INNOVATE), PTDC/EEI-AUT/5442/2014) 
Instituto de Telecomunicações, UID/Multi/04326/2013 
Associated Laboratory – Institute of Nanoscience and Nanotechnology (POCI-01-0145-FEDER-016623) 
PTDC/CTM-NAN/3146/2014 
Serial title, monograph or event: Scientific Reports
Volume: 7
Issue: 1
Abstract: Ultra-sensitive electrodes for extracellular recordings were fabricated and electrically characterized. A signal detection limit defined by a noise level of 0.3-0.4 μV for a bandwidth of 12.5 Hz was achieved. To obtain this high sensitivity, large area (4 mm2) electrodes were used. The electrode surface is also micro-structured with an array of gold mushroom-like shapes to further enhance the active area. In comparison with a flat gold surface, the micro-structured surface increases the capacitance of the electrode/electrolyte interface by 54%. The electrode low impedance and low noise enable the detection of weak and low frequency quasi-periodic signals produced by astrocytes populations that thus far had remained inaccessible using conventional extracellular electrodes. Signals with 5 μV in amplitude and lasting for 5-10 s were measured, with a peak-to-peak signal-to-noise ratio of 16. The electrodes and the methodology developed here can be used as an ultrasensitive electrophysiological tool to reveal the synchronization dynamics of ultra-slow ionic signalling between non-electrogenic cells.
URI: https://hdl.handle.net/10316/108387
ISSN: 2045-2322
DOI: 10.1038/s41598-017-14697-y
Rights: openAccess
Appears in Collections:FCTUC Eng.Electrotécnica - Artigos em Revistas Internacionais
I&D IT - Artigos em Revistas Internacionais

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