Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/108387
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mestre, Ana L. G. | - |
dc.contributor.author | Cerquido, Mónica | - |
dc.contributor.author | Inácio, Pedro M. C. | - |
dc.contributor.author | Asgarifar, Sanaz | - |
dc.contributor.author | Lourenço, Ana S. | - |
dc.contributor.author | Cristiano, Maria L. S. | - |
dc.contributor.author | Aguiar, Paulo | - |
dc.contributor.author | Medeiros, Maria C. R. | - |
dc.contributor.author | Araújo, Inês M. | - |
dc.contributor.author | Ventura, João | - |
dc.contributor.author | Gomes, Henrique L. | - |
dc.date.accessioned | 2023-08-28T10:25:36Z | - |
dc.date.available | 2023-08-28T10:25:36Z | - |
dc.date.issued | 2017-10-27 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10316/108387 | - |
dc.description.abstract | Ultra-sensitive electrodes for extracellular recordings were fabricated and electrically characterized. A signal detection limit defined by a noise level of 0.3-0.4 μV for a bandwidth of 12.5 Hz was achieved. To obtain this high sensitivity, large area (4 mm2) electrodes were used. The electrode surface is also micro-structured with an array of gold mushroom-like shapes to further enhance the active area. In comparison with a flat gold surface, the micro-structured surface increases the capacitance of the electrode/electrolyte interface by 54%. The electrode low impedance and low noise enable the detection of weak and low frequency quasi-periodic signals produced by astrocytes populations that thus far had remained inaccessible using conventional extracellular electrodes. Signals with 5 μV in amplitude and lasting for 5-10 s were measured, with a peak-to-peak signal-to-noise ratio of 16. The electrodes and the methodology developed here can be used as an ultrasensitive electrophysiological tool to reveal the synchronization dynamics of ultra-slow ionic signalling between non-electrogenic cells. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.relation | project “Implantable organic devices for advanced therapies” (INNOVATE), PTDC/EEI-AUT/5442/2014) | pt |
dc.relation | Instituto de Telecomunicações, UID/Multi/04326/2013 | pt |
dc.relation | Associated Laboratory – Institute of Nanoscience and Nanotechnology (POCI-01-0145-FEDER-016623) | pt |
dc.relation | PTDC/CTM-NAN/3146/2014 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.title | Ultrasensitive gold micro-structured electrodes enabling the detection of extra-cellular long-lasting potentials in astrocytes populations | pt |
dc.type | article | pt |
degois.publication.firstPage | 14284 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Scientific Reports | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1038/s41598-017-14697-y | - |
degois.publication.volume | 7 | pt |
dc.date.embargo | 2017-10-27 | * |
dc.identifier.pmid | 29079771 | - |
uc.date.periodoEmbargo | 0 | pt |
dc.identifier.eissn | 2045-2322 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
crisitem.project.grantno | Centre of Marine Sciences | - |
crisitem.author.orcid | 0000-0003-2277-2848 | - |
Appears in Collections: | FCTUC Eng.Electrotécnica - Artigos em Revistas Internacionais I&D IT - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Ultrasensitive-gold-microstructured-electrodes-enabling-the-detection-of-extracellular-longlasting-potentials-in-astrocytes-populationsScientific-Reports.pdf | 2.58 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
14
checked on Aug 26, 2024
WEB OF SCIENCETM
Citations
14
checked on Aug 2, 2024
Page view(s)
73
checked on Aug 28, 2024
Download(s)
61
checked on Aug 28, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License