Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/108387
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dc.contributor.authorMestre, Ana L. G.-
dc.contributor.authorCerquido, Mónica-
dc.contributor.authorInácio, Pedro M. C.-
dc.contributor.authorAsgarifar, Sanaz-
dc.contributor.authorLourenço, Ana S.-
dc.contributor.authorCristiano, Maria L. S.-
dc.contributor.authorAguiar, Paulo-
dc.contributor.authorMedeiros, Maria C. R.-
dc.contributor.authorAraújo, Inês M.-
dc.contributor.authorVentura, João-
dc.contributor.authorGomes, Henrique L.-
dc.date.accessioned2023-08-28T10:25:36Z-
dc.date.available2023-08-28T10:25:36Z-
dc.date.issued2017-10-27-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://hdl.handle.net/10316/108387-
dc.description.abstractUltra-sensitive electrodes for extracellular recordings were fabricated and electrically characterized. A signal detection limit defined by a noise level of 0.3-0.4 μV for a bandwidth of 12.5 Hz was achieved. To obtain this high sensitivity, large area (4 mm2) electrodes were used. The electrode surface is also micro-structured with an array of gold mushroom-like shapes to further enhance the active area. In comparison with a flat gold surface, the micro-structured surface increases the capacitance of the electrode/electrolyte interface by 54%. The electrode low impedance and low noise enable the detection of weak and low frequency quasi-periodic signals produced by astrocytes populations that thus far had remained inaccessible using conventional extracellular electrodes. Signals with 5 μV in amplitude and lasting for 5-10 s were measured, with a peak-to-peak signal-to-noise ratio of 16. The electrodes and the methodology developed here can be used as an ultrasensitive electrophysiological tool to reveal the synchronization dynamics of ultra-slow ionic signalling between non-electrogenic cells.pt
dc.language.isoengpt
dc.publisherSpringer Naturept
dc.relationproject “Implantable organic devices for advanced therapies” (INNOVATE), PTDC/EEI-AUT/5442/2014)pt
dc.relationInstituto de Telecomunicações, UID/Multi/04326/2013pt
dc.relationAssociated Laboratory – Institute of Nanoscience and Nanotechnology (POCI-01-0145-FEDER-016623)pt
dc.relationPTDC/CTM-NAN/3146/2014pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.titleUltrasensitive gold micro-structured electrodes enabling the detection of extra-cellular long-lasting potentials in astrocytes populationspt
dc.typearticlept
degois.publication.firstPage14284pt
degois.publication.issue1pt
degois.publication.titleScientific Reportspt
dc.peerreviewedyespt
dc.identifier.doi10.1038/s41598-017-14697-y-
degois.publication.volume7pt
dc.date.embargo2017-10-27*
dc.identifier.pmid29079771-
uc.date.periodoEmbargo0pt
dc.identifier.eissn2045-2322-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.cerifentitytypePublications-
crisitem.author.orcid0000-0003-2277-2848-
Appears in Collections:FCTUC Eng.Electrotécnica - Artigos em Revistas Internacionais
I&D IT - Artigos em Revistas Internacionais
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