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https://hdl.handle.net/10316/108362
Título: | d-α-tocopherol nanoemulsions: Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity | Autor: | Teixeira, M. C. Severino, P. Andreani, T. Boonme, P. Santini, A. Silva, A. M. Souto, E. B. |
Palavras-chave: | D-α-tocopherol; Nanoemulsions; High-pressure homogenization; Rheology; Osmolarity; Surface tension; Caco-2-cells; Cytotoxicity | Data: | Fev-2017 | Editora: | King Saud University | Projeto: | UID/AGR/04033/2013 POCI-01-0145- FEDER-006958 UID/QUI/50006/2013 M-ERA-NET/0004/ 2015-PAIRED, receiving financial support from FCT/MEC through national funds, and co-financed by FEDER, under the Partnership Agreement PT2020. |
Título da revista, periódico, livro ou evento: | Saudi Pharmaceutical Journal | Volume: | 25 | Número: | 2 | Resumo: | The aim of this study was the assessment of the physicochemical stability of d-α-tocopherol formulated in medium chain triglyceride nanoemulsions, stabilized with Tween®80 and Lipoid®S75 as surfactant and co-surfactant, respectively. d-α-tocopherol was selected as active ingredient because of its well-recognized interesting anti-oxidant properties (such as radical scavenger) for food and pharmaceutical industries. A series of nanoemulsions of mean droplet size below 90 nm (polydispersity index < 0.15) have been produced by high-pressure homogenization, and their surface electrical charge (zeta potential), pH, surface tension, osmolarity, and rheological behavior, were characterized as a function of the d-α-tocopherol loading. In vitro studies in Caco-2 cell lines confirmed the safety profile of the developed nanoemulsions with percentage of cell viability above 90% for all formulations. | URI: | https://hdl.handle.net/10316/108362 | ISSN: | 1319-0164 | DOI: | 10.1016/j.jsps.2016.06.004 | Direitos: | openAccess |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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D-α-tocopherol nanoemulsions Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity.pdf | 531.38 kB | Adobe PDF | Ver/Abrir |
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