Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/108362
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Teixeira, M. C. | - |
dc.contributor.author | Severino, P. | - |
dc.contributor.author | Andreani, T. | - |
dc.contributor.author | Boonme, P. | - |
dc.contributor.author | Santini, A. | - |
dc.contributor.author | Silva, A. M. | - |
dc.contributor.author | Souto, E. B. | - |
dc.date.accessioned | 2023-08-25T11:32:36Z | - |
dc.date.available | 2023-08-25T11:32:36Z | - |
dc.date.issued | 2017-02 | - |
dc.identifier.issn | 1319-0164 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/108362 | - |
dc.description.abstract | The aim of this study was the assessment of the physicochemical stability of d-α-tocopherol formulated in medium chain triglyceride nanoemulsions, stabilized with Tween®80 and Lipoid®S75 as surfactant and co-surfactant, respectively. d-α-tocopherol was selected as active ingredient because of its well-recognized interesting anti-oxidant properties (such as radical scavenger) for food and pharmaceutical industries. A series of nanoemulsions of mean droplet size below 90 nm (polydispersity index < 0.15) have been produced by high-pressure homogenization, and their surface electrical charge (zeta potential), pH, surface tension, osmolarity, and rheological behavior, were characterized as a function of the d-α-tocopherol loading. In vitro studies in Caco-2 cell lines confirmed the safety profile of the developed nanoemulsions with percentage of cell viability above 90% for all formulations. | pt |
dc.language.iso | eng | pt |
dc.publisher | King Saud University | pt |
dc.relation | UID/AGR/04033/2013 | pt |
dc.relation | POCI-01-0145- FEDER-006958 | pt |
dc.relation | UID/QUI/50006/2013 | pt |
dc.relation | M-ERA-NET/0004/ 2015-PAIRED, receiving financial support from FCT/MEC through national funds, and co-financed by FEDER, under the Partnership Agreement PT2020. | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.subject | D-α-tocopherol | pt |
dc.subject | Nanoemulsions | pt |
dc.subject | High-pressure homogenization | pt |
dc.subject | Rheology | pt |
dc.subject | Osmolarity | pt |
dc.subject | Surface tension | pt |
dc.subject | Caco-2-cells | pt |
dc.subject | Cytotoxicity | pt |
dc.title | d-α-tocopherol nanoemulsions: Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity | pt |
dc.type | article | - |
degois.publication.firstPage | 231 | pt |
degois.publication.lastPage | 235 | pt |
degois.publication.issue | 2 | pt |
degois.publication.title | Saudi Pharmaceutical Journal | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.jsps.2016.06.004 | pt |
degois.publication.volume | 25 | pt |
dc.date.embargo | 2017-02-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairetype | article | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.orcid | 0000-0002-9737-6017 | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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D-α-tocopherol nanoemulsions Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity.pdf | 531.38 kB | Adobe PDF | View/Open |
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This item is licensed under a Creative Commons License