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Title: d-α-tocopherol nanoemulsions: Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity
Authors: Teixeira, M. C. 
Severino, P.
Andreani, T.
Boonme, P.
Santini, A.
Silva, A. M.
Souto, E. B. 
Keywords: D-α-tocopherol; Nanoemulsions; High-pressure homogenization; Rheology; Osmolarity; Surface tension; Caco-2-cells; Cytotoxicity
Issue Date: Feb-2017
Publisher: King Saud University
Project: UID/AGR/04033/2013 
POCI-01-0145- FEDER-006958 
M-ERA-NET/0004/ 2015-PAIRED, receiving financial support from FCT/MEC through national funds, and co-financed by FEDER, under the Partnership Agreement PT2020. 
Serial title, monograph or event: Saudi Pharmaceutical Journal
Volume: 25
Issue: 2
Abstract: The aim of this study was the assessment of the physicochemical stability of d-α-tocopherol formulated in medium chain triglyceride nanoemulsions, stabilized with Tween®80 and Lipoid®S75 as surfactant and co-surfactant, respectively. d-α-tocopherol was selected as active ingredient because of its well-recognized interesting anti-oxidant properties (such as radical scavenger) for food and pharmaceutical industries. A series of nanoemulsions of mean droplet size below 90 nm (polydispersity index < 0.15) have been produced by high-pressure homogenization, and their surface electrical charge (zeta potential), pH, surface tension, osmolarity, and rheological behavior, were characterized as a function of the d-α-tocopherol loading. In vitro studies in Caco-2 cell lines confirmed the safety profile of the developed nanoemulsions with percentage of cell viability above 90% for all formulations.
ISSN: 1319-0164
DOI: 10.1016/j.jsps.2016.06.004
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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