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Title: Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications
Authors: Costa, Pedro
Metello, Luís
Alves, Francisco 
Naia, M. Duarte 
Keywords: cyclotron; PET; titanium-45; unconventional radionuclides
Issue Date: 2018
Publisher: MDPI
Serial title, monograph or event: Instruments
Volume: 2
Issue: 2
Abstract: Positron emitting radionuclides are used to label different compounds, allowing the study of the major biological systems using PET (positron emission tomography) imaging. Although there are several radionuclides suited for PET imaging, routine clinical applications are still based on a restrict group constituted by 18F, 11C, and, more recently, 68Ga. However, with the enlarged availability of low-energy cyclotrons and technical improvements in radionuclide production, the use of unconventional radionuclides is progressively more common. Several examples of unconventional radionuclides for PET imaging are being suggested, and 45Ti could be suggested as a model, due to its interesting properties such as its abundant positron emission (85%), reduced positron energy ( + endpoint energy = 1040 keV), physical half-life of 3.09 h, and interesting chemical properties. This review aims to introduce the role of cyclotrons in the production of unconventional radionuclides for PET imaging while using 45Ti as an example to explore the potential biomedical applications of those radionuclides in PET imaging.
ISSN: 2410-390X
DOI: 10.3390/instruments2020008
Rights: openAccess
Appears in Collections:I&D CEMMPRE - Artigos em Revistas Internacionais
I&D ICNAS - Artigos em Revistas Internacionais

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