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Title: Automated Purification of Radiometals Produced by Liquid Targets
Authors: Alves, Vítor H. P. 
Carmo, Sérgio do 
Alves, Francisco 
Abrunhosa, Antero 
Keywords: liquid targets; medical cyclotron; radiometals; gallium-68; copper-64; copper-61; purification; disposable kit; radiopharmaceuticals
Issue Date: 2018
Publisher: MDPI
Serial title, monograph or event: Instruments
Volume: 2
Issue: 3
Abstract: An automated process for the production and purification of radiometals produced by irradiating liquid targets in a medical cyclotron, using a commercially available module, has been developed. The method is suitable for the production and purification of radiometals such as 68Ga, 64Cu and 61Cu through irradiation of liquid targets and is important for producing high specific activity radioisotopes with a substantial reduction in processing time and cost when compared with the solid target approach. The “liquid target” process also eliminates the need for pre- and post-irradiation target preparation and simplifies the transfer of irradiated material from target to hotcell. A 68GaCl3 solution can be obtained in about 35 min with an average yield of 73.9 6.7% in less than 10 mL of volume. 64CuCl2 solutions can be obtained with an average yield of 81.2 7.8% in about 1 h of processing time. A dedicated single-use disposable kit is used on a commercial IBA Synthera® extension module.
ISSN: 2410-390X
DOI: 10.3390/instruments2030017
Rights: openAccess
Appears in Collections:I&D ICNAS - Artigos em Revistas Internacionais

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