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https://hdl.handle.net/10316/107530
Título: | A New Tool in the Quest for Biocompatible Phthalocyanines: Palladium Catalyzed Aminocarbonylation for Amide Substituted Phthalonitriles and Illustrative Phthalocyanines Thereof | Autor: | Tomé, Vanessa Almeida Calvete, Mário J. F. Vinagreiro, Carolina S. Aroso, Rafael T. Pereira, Mariette M. |
Palavras-chave: | peptide bond; phthalonitriles; phthalocyanines; aminocarbonylation; palladium catalysts | Data: | 2018 | Editora: | MDPI | Projeto: | PEst-OE/QUI/UI0313/2014 PT2020 POCI-01-0145-FEDER-027996 PTDC/QEQ-MED/3521/2014 PTDC/QUI-OUT/27996/2017 SFRH/BPD/99698/2014 PD/BD/128317/2017 PD/BD/128318/2017 PD/BI/135341/2017 |
Título da revista, periódico, livro ou evento: | Catalysts | Volume: | 8 | Número: | 10 | Resumo: | The amide peptide bond type linkage is one of the most natural conjugations available, present in many biological synthons and pharmaceutical drugs. Hence, aiming the direct conjugation of potentially biologically active compounds to phthalocyanines, herein we disclose a new strategy for direct modulation of phthalonitriles, inspired by an attractive synthetic strategy for the preparation of carboxamides based on palladium-catalyzed aminocarbonylation of aryl halides in the presence of carbon monoxide (CO) which, to our knowledge, has never been used to prepare amide-substituted phthalonitriles, the natural precursors for the synthesis of phthalocyanines. Some examples of phthalocyanines prepared thereof are also reported, along with their full spectroscopic characterization and photophysical properties initial assessment. | URI: | https://hdl.handle.net/10316/107530 | ISSN: | 2073-4344 | DOI: | 10.3390/catal8100480 | Direitos: | openAccess |
Aparece nas coleções: | I&D CQC - Artigos em Revistas Internacionais |
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A-new-tool-in-the-quest-for-biocompatible-phthalocyanines-Palladium-catalyzed-aminocarbonylation-for-amide-substituted-phthalonitriles-and-illustrative-phthalocyanines-thereofCatalysts.pdf | 8.76 MB | Adobe PDF | Ver/Abrir |
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