Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/107530
Title: A New Tool in the Quest for Biocompatible Phthalocyanines: Palladium Catalyzed Aminocarbonylation for Amide Substituted Phthalonitriles and Illustrative Phthalocyanines Thereof
Authors: Tomé, Vanessa Almeida 
Calvete, Mário J. F. 
Vinagreiro, Carolina S. 
Aroso, Rafael T. 
Pereira, Mariette M. 
Keywords: peptide bond; phthalonitriles; phthalocyanines; aminocarbonylation; palladium catalysts
Issue Date: 2018
Publisher: MDPI
Project: PEst-OE/QUI/UI0313/2014 
PT2020 POCI-01-0145-FEDER-027996 
PTDC/QEQ-MED/3521/2014 
PTDC/QUI-OUT/27996/2017 
SFRH/BPD/99698/2014 
PD/BD/128317/2017 
PD/BD/128318/2017 
PD/BI/135341/2017 
Serial title, monograph or event: Catalysts
Volume: 8
Issue: 10
Abstract: The amide peptide bond type linkage is one of the most natural conjugations available, present in many biological synthons and pharmaceutical drugs. Hence, aiming the direct conjugation of potentially biologically active compounds to phthalocyanines, herein we disclose a new strategy for direct modulation of phthalonitriles, inspired by an attractive synthetic strategy for the preparation of carboxamides based on palladium-catalyzed aminocarbonylation of aryl halides in the presence of carbon monoxide (CO) which, to our knowledge, has never been used to prepare amide-substituted phthalonitriles, the natural precursors for the synthesis of phthalocyanines. Some examples of phthalocyanines prepared thereof are also reported, along with their full spectroscopic characterization and photophysical properties initial assessment.
URI: https://hdl.handle.net/10316/107530
ISSN: 2073-4344
DOI: 10.3390/catal8100480
Rights: openAccess
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais

Show full item record

SCOPUSTM   
Citations

5
checked on Apr 22, 2024

WEB OF SCIENCETM
Citations

4
checked on Apr 2, 2024

Page view(s)

54
checked on Apr 16, 2024

Download(s)

12
checked on Apr 16, 2024

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons