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https://hdl.handle.net/10316/107381
Título: | Thrombophilic risk factors for retinal vein occlusion | Autor: | Vieira, Maria J. Campos, António Carmo, Anália do Arruda, Henrique Martins, Joana Sousa, João P. |
Data: | 12-Dez-2019 | Editora: | Springer Nature | Título da revista, periódico, livro ou evento: | Scientific Reports | Volume: | 9 | Número: | 1 | Resumo: | The aim is to study risk factors for retinal vein occlusion (RVO), such as thrombophilic and cardiovascular risk factors (CRF). A retrospective consecutive case series of 60 patients with RVO was made, tested for CRF, hyperhomocysteinemia, lupic anticoagulant, antiphospholipid antibody and 5 gene variants: factor V (FV) Leiden (G1691A), factor II (PT G20210A), 5,1-methylenetetra-hydrofolate reductase (MTHFR; 677 C > T and 1298 A > C), plasminogen activator inhibitor 1 (PAI-1; 4 G/5 G). More than 1 CRF were present in 36 patients (60%), which had a significantly higher mean age at diagnosis (66.7 ± 12.9 versus 59.5 ± 13.7 with ≤1 CRF, [t(57) = -2.05, p = 0.045, d = 0.54). Patients with thermolabile MTHFR forms with decreased enzyme activity (T677T or C677T/A1298C) had a significant lower mean age [57.6 ± 15.1; t (58) = 3.32; p = 0.002; d = 0.846] than patients with normal MTHFR enzyme activity (68.5 ± 10.2). Regarding CRF and thermolabile forms of MTHFR, the mean age at diagnosis could be significantly predicted [F(2,56) = 7.18; p = 0.002] by the equation: 64.8 - 10.3 × (thermolabile MTHFR) - 5.31 × ( ≤ 1CRF). Screening of MTHFR polymorphisms may be useful in younger RVO patients, particularly when multiple CRF are absent. | URI: | https://hdl.handle.net/10316/107381 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-019-55456-5 | Direitos: | openAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais |
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Thrombophilic-risk-factors-for-retinal-vein-occlusionScientific-Reports.pdf | 989.86 kB | Adobe PDF | Ver/Abrir |
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