Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/107381
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dc.contributor.authorVieira, Maria J.-
dc.contributor.authorCampos, António-
dc.contributor.authorCarmo, Anália do-
dc.contributor.authorArruda, Henrique-
dc.contributor.authorMartins, Joana-
dc.contributor.authorSousa, João P.-
dc.date.accessioned2023-07-07T07:43:50Z-
dc.date.available2023-07-07T07:43:50Z-
dc.date.issued2019-12-12-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://hdl.handle.net/10316/107381-
dc.description.abstractThe aim is to study risk factors for retinal vein occlusion (RVO), such as thrombophilic and cardiovascular risk factors (CRF). A retrospective consecutive case series of 60 patients with RVO was made, tested for CRF, hyperhomocysteinemia, lupic anticoagulant, antiphospholipid antibody and 5 gene variants: factor V (FV) Leiden (G1691A), factor II (PT G20210A), 5,1-methylenetetra-hydrofolate reductase (MTHFR; 677 C > T and 1298 A > C), plasminogen activator inhibitor 1 (PAI-1; 4 G/5 G). More than 1 CRF were present in 36 patients (60%), which had a significantly higher mean age at diagnosis (66.7 ± 12.9 versus 59.5 ± 13.7 with ≤1 CRF, [t(57) = -2.05, p = 0.045, d = 0.54). Patients with thermolabile MTHFR forms with decreased enzyme activity (T677T or C677T/A1298C) had a significant lower mean age [57.6 ± 15.1; t (58) = 3.32; p = 0.002; d = 0.846] than patients with normal MTHFR enzyme activity (68.5 ± 10.2). Regarding CRF and thermolabile forms of MTHFR, the mean age at diagnosis could be significantly predicted [F(2,56) = 7.18; p = 0.002] by the equation: 64.8 - 10.3 × (thermolabile MTHFR) - 5.31 × ( ≤ 1CRF). Screening of MTHFR polymorphisms may be useful in younger RVO patients, particularly when multiple CRF are absent.pt
dc.language.isoengpt
dc.publisherSpringer Naturept
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.titleThrombophilic risk factors for retinal vein occlusionpt
dc.typearticlept
degois.publication.firstPage18972pt
degois.publication.issue1pt
degois.publication.titleScientific Reportspt
dc.peerreviewedyespt
dc.identifier.doi10.1038/s41598-019-55456-5-
degois.publication.volume9pt
dc.date.embargo2019-12-12*
dc.identifier.pmid31831825-
uc.date.periodoEmbargo0pt
dc.identifier.eissn2045-2322-
item.languageiso639-1en-
item.openairetypearticle-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextCom Texto completo-
item.cerifentitytypePublications-
crisitem.author.researchunitICBR Coimbra Institute for Clinical and Biomedical Research-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.parentresearchunitFaculty of Medicine-
crisitem.author.orcid0000-0003-0490-5889-
crisitem.author.orcid0000-0002-7704-4736-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais
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