Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/107381
DC Field | Value | Language |
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dc.contributor.author | Vieira, Maria J. | - |
dc.contributor.author | Campos, António | - |
dc.contributor.author | Carmo, Anália do | - |
dc.contributor.author | Arruda, Henrique | - |
dc.contributor.author | Martins, Joana | - |
dc.contributor.author | Sousa, João P. | - |
dc.date.accessioned | 2023-07-07T07:43:50Z | - |
dc.date.available | 2023-07-07T07:43:50Z | - |
dc.date.issued | 2019-12-12 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10316/107381 | - |
dc.description.abstract | The aim is to study risk factors for retinal vein occlusion (RVO), such as thrombophilic and cardiovascular risk factors (CRF). A retrospective consecutive case series of 60 patients with RVO was made, tested for CRF, hyperhomocysteinemia, lupic anticoagulant, antiphospholipid antibody and 5 gene variants: factor V (FV) Leiden (G1691A), factor II (PT G20210A), 5,1-methylenetetra-hydrofolate reductase (MTHFR; 677 C > T and 1298 A > C), plasminogen activator inhibitor 1 (PAI-1; 4 G/5 G). More than 1 CRF were present in 36 patients (60%), which had a significantly higher mean age at diagnosis (66.7 ± 12.9 versus 59.5 ± 13.7 with ≤1 CRF, [t(57) = -2.05, p = 0.045, d = 0.54). Patients with thermolabile MTHFR forms with decreased enzyme activity (T677T or C677T/A1298C) had a significant lower mean age [57.6 ± 15.1; t (58) = 3.32; p = 0.002; d = 0.846] than patients with normal MTHFR enzyme activity (68.5 ± 10.2). Regarding CRF and thermolabile forms of MTHFR, the mean age at diagnosis could be significantly predicted [F(2,56) = 7.18; p = 0.002] by the equation: 64.8 - 10.3 × (thermolabile MTHFR) - 5.31 × ( ≤ 1CRF). Screening of MTHFR polymorphisms may be useful in younger RVO patients, particularly when multiple CRF are absent. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.title | Thrombophilic risk factors for retinal vein occlusion | pt |
dc.type | article | pt |
degois.publication.firstPage | 18972 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Scientific Reports | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1038/s41598-019-55456-5 | - |
degois.publication.volume | 9 | pt |
dc.date.embargo | 2019-12-12 | * |
dc.identifier.pmid | 31831825 | - |
uc.date.periodoEmbargo | 0 | pt |
dc.identifier.eissn | 2045-2322 | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0003-0490-5889 | - |
crisitem.author.orcid | 0000-0002-7704-4736 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais |
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Thrombophilic-risk-factors-for-retinal-vein-occlusionScientific-Reports.pdf | 989.86 kB | Adobe PDF | View/Open |
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