Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/107211
Título: | Clotrimazole-Loaded Mediterranean Essential Oils NLC: A Synergic Treatment of Candida Skin Infections | Autor: | Carbone, Claudia Teixeira, Maria do Céu Sousa, Maria Céu Martins-Gomes, Carlos Silva, Amelia M. Souto, Eliana Maria Barbosa Musumeci, Teresa |
Palavras-chave: | Rosmarinus officinalis L.; Lavandula x intermedia “Sumian”; Origanum vulgare subsp. hirtum; factorial design; stability; Turbiscan; Lumisizer; DSC; cytotoxicity; MIC | Data: | 13-Mai-2019 | Editora: | MDPI | Projeto: | Research Funding for University of Catania, under Project Piano per la Ricerca 2016–2018—Linea Di Intervento 2 “Dotazione Ordinaria” cod. 57722172106 | Título da revista, periódico, livro ou evento: | Pharmaceutics | Volume: | 11 | Número: | 5 | Resumo: | The increasing development of resistance of Candida species to traditional drugs represents a great challenge to the medical field for the treatment of skin infections. Essential oils were recently proposed to increase drug effectiveness. Herein, we developed and optimized (23 full factorial design) Mediterranean essential oil (Rosmarinus officinalis, Lavandula x intermedia "Sumian", Origanum vulgare subsp. hirtum) lipid nanoparticles for clotrimazole delivery, exploring the potential synergistic effects against Candida spp. Small sized nanoparticles (<100 nm) with a very broad size distribution (PDI < 0.15) and long-term stability were successfully prepared. Results of the in vitro biosafety on HaCaT (normal cell line) and A431 (tumoral cell line), allowed us to select Lavandula and Rosmarinus as anti-proliferative agents with the potential to be used as co-adjuvants in the treatment of non-tumoral proliferative dermal diseases. Results of calorimetric studies on biomembrane models, confirmed the potential antimicrobial activity of the selected oils due to their interaction with membrane permeabilization. Nanoparticles provided a prolonged in vitro release of clotrimazole. In vitro studies against Candida albicans, Candida krusei and Candida parapsilosis, showed an increase of the antifungal activity of clotrimazole-loaded nanoparticles prepared with Lavandula or Rosmarinus, thus confirming nanostructured lipid carriers (NLC) containing Mediterranean essential oils represent a promising strategy to improve drug effectiveness against topical candidiasis. | URI: | https://hdl.handle.net/10316/107211 | ISSN: | 1999-4923 | DOI: | 10.3390/pharmaceutics11050231 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Clotrimazoleloaded-mediterranean-essential-oils-NLC-A-synergic-treatment-of-Candida-skin-infectionsPharmaceutics.pdf | 2.83 MB | Adobe PDF | Ver/Abrir |
Citações SCOPUSTM
68
Visto em 14/out/2024
Citações WEB OF SCIENCETM
54
Visto em 2/out/2024
Visualizações de página
87
Visto em 15/out/2024
Downloads
25
Visto em 15/out/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons