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https://hdl.handle.net/10316/107157
Título: | Multi-Organ NMR Metabolomics to Assess In Vivo Overall Metabolic Impact of Cisplatin in Mice | Autor: | Carneiro, Tatiana J. Araújo, Rita Vojtek, Martin Gonçalves-Monteiro, Salomé Diniz, Carmen Batista de Carvalho, Ana L. M. Marques, Maria Paula Gil, Ana M |
Palavras-chave: | cisplatin; mice; mouse model; in vivo; NMR; metabolomics; metabonomics; kidney; liver; breast tissue | Data: | 13-Nov-2019 | Editora: | MDPI | Projeto: | UID/CTM/50011/2019 UID/QUI/50006/2019 UID/MULTI/ 00070/2019 POCI-01-0145-FEDER-0016786 Centro-01-0145-FEDER-029956 PD/BD/135460/2017 PTDC/QEQ-MED/1890/2014 SFRH/BD/145920/2019 |
Título da revista, periódico, livro ou evento: | Metabolites | Volume: | 9 | Número: | 11 | Resumo: | This work describes, to our knowledge, the first NMR metabolomics analysis of mice kidney, liver, and breast tissue in response to cisplatin exposure, in search of early metabolic signatures of cisplatin biotoxicity. Balb/c mice were exposed to a single 3.5 mg/kg dose of cisplatin and then euthanized; organs (kidney, liver, breast tissue) were collected at 1, 12, and 48 h. Polar tissue extracts were analyzed by NMR spectroscopy, and the resulting spectra were studied by multivariate and univariate analyses. The results enabled the identification of the most significant deviant metabolite levels at each time point, and for each tissue type, and showed that the largest metabolic impact occurs for kidney, as early as 1 h post-injection. Kidney tissue showed a marked depletion in several amino acids, comprised in an overall 13-metabolites signature. The highest number of changes in all tissues was noted at 12 h, although many of those recovered to control levels at 48 h, with the exception of some persistently deviant tissue-specific metabolites, thus enabling the identification of relatively longer-term effects of cDDP. This work reports, for the first time, early (1-48 h) concomitant effects of cDDP in kidney, liver, and breast tissue metabolism, thus contributing to the understanding of multi-organ cDDP biotoxicity. | URI: | https://hdl.handle.net/10316/107157 | ISSN: | 2218-1989 | DOI: | 10.3390/metabo9110279 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais I&D QFM-UC - Artigos em Revistas Internacionais |
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Multiorgan-NMR-metabolomics-to-assess-in-vivo-overall-metabolic-impact-of-cisplatin-in-miceMetabolites.pdf | 2.55 MB | Adobe PDF | Ver/Abrir |
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