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https://hdl.handle.net/10316/106212
Título: | Engineering optical tools for remotely controlled brain stimulation and regeneration | Autor: | Rodrigues, Artur Filipe Rebelo, Catarina Reis, Tiago Simões, Susana Bernardino, Liliana Peça, João Ferreira, Lino |
Data: | 2023 | Editora: | Royal Society of Chemistry | Projeto: | info:eu-repo/grantAgreement/EC/H2020/952266/EU/RESEarch for healThy AGEING | Título da revista, periódico, livro ou evento: | Biomaterials Science | Resumo: | Neurological disorders are one of the world's leading medical and societal challenges due to the lack of efficacy of the first line treatment. Although pharmacological and non-pharmacological interventions have been employed with the aim of regulating neuronal activity and survival, they have failed to avoid symptom relapse and disease progression in the vast majority of patients. In the last 5 years, advanced drug delivery systems delivering bioactive molecules and neuromodulation strategies have been developed to promote tissue regeneration and remodel neuronal circuitry. However, both approaches still have limited spatial and temporal precision over the desired target regions. While external stimuli such as electromagnetic fields and ultrasound have been employed in the clinic for non-invasive neuromodulation, they do not have the capability of offering single-cell spatial resolution as light stimulation. Herein, we review the latest progress in this area of study and discuss the prospects of using light-responsive nanomaterials to achieve on-demand delivery of drugs and neuromodulation, with the aim of achieving brain stimulation and regeneration. | URI: | https://hdl.handle.net/10316/106212 | ISSN: | 2047-4849 2047-4830 |
DOI: | 10.1039/D2BM02059A | Direitos: | embargoedAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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BM_d2bm02059a_session_report.pdf | 769.9 kB | Adobe PDF | Ver/Abrir |
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