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https://hdl.handle.net/10316/105847
Title: | Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions | Authors: | Catarata, Maria Joana Ribeiro, Ricardo Oliveira, Maria José Cordeiro, Carlos Robalo Medeiros, Rui |
Keywords: | lung cancer; renin-angiotensin; hypoxia; tumor microenvironment | Issue Date: | 3-Jun-2020 | Publisher: | MDPI | Project: | Associação de Estudos Respiratórios (507593367) | Serial title, monograph or event: | Cancers | Volume: | 12 | Issue: | 6 | Abstract: | The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer. | URI: | https://hdl.handle.net/10316/105847 | ISSN: | 2072-6694 | DOI: | 10.3390/cancers12061457 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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Reninangiotensin-system-in-lung-tumor-and-microenvironment-interactionsCancers.pdf | 3.25 MB | Adobe PDF | View/Open |
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