Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/105847
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Catarata, Maria Joana | - |
dc.contributor.author | Ribeiro, Ricardo | - |
dc.contributor.author | Oliveira, Maria José | - |
dc.contributor.author | Cordeiro, Carlos Robalo | - |
dc.contributor.author | Medeiros, Rui | - |
dc.date.accessioned | 2023-03-10T12:59:16Z | - |
dc.date.available | 2023-03-10T12:59:16Z | - |
dc.date.issued | 2020-06-03 | - |
dc.identifier.issn | 2072-6694 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/105847 | - |
dc.description.abstract | The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | Associação de Estudos Respiratórios (507593367) | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | lung cancer | pt |
dc.subject | renin-angiotensin | pt |
dc.subject | hypoxia | pt |
dc.subject | tumor microenvironment | pt |
dc.title | Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions | pt |
dc.type | article | - |
degois.publication.firstPage | 1457 | pt |
degois.publication.issue | 6 | pt |
degois.publication.title | Cancers | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/cancers12061457 | pt |
degois.publication.volume | 12 | pt |
dc.date.embargo | 2020-06-03 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | iNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG and ITQB) | - |
crisitem.author.orcid | 0000-0002-8264-3856 | - |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Reninangiotensin-system-in-lung-tumor-and-microenvironment-interactionsCancers.pdf | 3.25 MB | Adobe PDF | Ver/Abrir |
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