Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/105847
Title: Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions
Authors: Catarata, Maria Joana
Ribeiro, Ricardo
Oliveira, Maria José 
Cordeiro, Carlos Robalo 
Medeiros, Rui 
Keywords: lung cancer; renin-angiotensin; hypoxia; tumor microenvironment
Issue Date: 3-Jun-2020
Publisher: MDPI
Project: Associação de Estudos Respiratórios (507593367) 
Serial title, monograph or event: Cancers
Volume: 12
Issue: 6
Abstract: The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer.
URI: https://hdl.handle.net/10316/105847
ISSN: 2072-6694
DOI: 10.3390/cancers12061457
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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