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https://hdl.handle.net/10316/105267
Title: | Formulation Effects in the Antioxidant Activity of Extract from the Leaves of Cymbopogon citratus (DC) Stapf | Authors: | Sousa, Raquel Figueirinha, Artur Batista, Maria Teresa Pina, Maria Eugénia |
Keywords: | Cymbopogon citratus; gelatine capsules; biological activity; chemical stability | Issue Date: | 27-Jul-2021 | Publisher: | MDPI | Project: | POCI/01/ 0145/FEDER/007265 UID/QUI/50006/2013 Programa de Cooperación Interreg V-A España–Portugal (POCTEP) 2014–2020 (project 0377_IBERPHENOL_6_E) UIDB/00102/2020 |
Serial title, monograph or event: | Molecules | Volume: | 26 | Issue: | 15 | Abstract: | Cymbopogon citratus DC (Stapf.) is a perennial grass and it is distributed around the world. It is used as a condiment for food and beverage flavouring in the form of infusions and decoctions of its dried leaves. Our previous studies have shown antioxidant, anti-inflammatory and gastroprotective activities for the infusion and its phenolic fractions. The aim of the present work was to develop oral dosage forms from a Cymbopogon citratus extract to be used as a functional food with antioxidant properties. Initially, an essential oil-free infusion was prepared, lyophilized and characterized by HPLC-PDA. Total phenols were quantified with the Folin-Ciocalteu method and the antioxidant activity was assessed by DPPH assay. Gelatine capsules containing the extract with different excipients, selected after DSC and IR trials, were prepared. A formulation exhibiting better antioxidant behaviour in a gastric environment was attained. These results suggest that the proposed formulation for this extract could be a valuable antioxidant product and, consequently, make an important contribution to "preventing" and minimizing diseases related to oxidative stress conditions. | URI: | https://hdl.handle.net/10316/105267 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules26154518 | Rights: | openAccess |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais I&D CERES - Artigos em Revistas Internacionais |
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