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Title: Recent Developments in New Therapeutic Agents against Alzheimer and Parkinson Diseases: In-Silico Approaches
Authors: Cruz-Vicente, Pedro
Passarinha, Luís A.
Silvestre, Samuel Martins 
Gallardo, Eugenia 
Keywords: neurodegenerative diseases; Parkinson’s Disease; Alzheimer’s Disease; computer-aided drug design; in silico studies
Issue Date: 11-Apr-2021
Publisher: MDPI AG
Project: Design of new Catechol-O-methyltransferase inhibitors with therapeutic potential for diseases of the central nervous system—Project Centro-01-0145-FEDER- 000019—C4—Centro de Competências em Cloud Computing 
CICS-UBI: UIDB/00709/2020 
UCIBIO: UIDP/04378/2020 
Serial title, monograph or event: Molecules
Volume: 26
Issue: 8
Abstract: Neurodegenerative diseases (ND), including Alzheimer's (AD) and Parkinson's Disease (PD), are becoming increasingly more common and are recognized as a social problem in modern societies. These disorders are characterized by a progressive neurodegeneration and are considered one of the main causes of disability and mortality worldwide. Currently, there is no existing cure for AD nor PD and the clinically used drugs aim only at symptomatic relief, and are not capable of stopping neurodegeneration. Over the last years, several drug candidates reached clinical trials phases, but they were suspended, mainly because of the unsatisfactory pharmacological benefits. Recently, the number of compounds developed using in silico approaches has been increasing at a promising rate, mainly evaluating the affinity for several macromolecular targets and applying filters to exclude compounds with potentially unfavorable pharmacokinetics. Thus, in this review, an overview of the current therapeutics in use for these two ND, the main targets in drug development, and the primary studies published in the last five years that used in silico approaches to design novel drug candidates for AD and PD treatment will be presented. In addition, future perspectives for the treatment of these ND will also be briefly discussed.
ISSN: 1420-3049
DOI: 10.3390/molecules26082193
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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