Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/105254
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dc.contributor.authorCruz-Vicente, Pedro-
dc.contributor.authorPassarinha, Luís A.-
dc.contributor.authorSilvestre, Samuel Martins-
dc.contributor.authorGallardo, Eugenia-
dc.date.accessioned2023-02-13T09:39:13Z-
dc.date.available2023-02-13T09:39:13Z-
dc.date.issued2021-04-11-
dc.identifier.issn1420-3049pt
dc.identifier.urihttps://hdl.handle.net/10316/105254-
dc.description.abstractNeurodegenerative diseases (ND), including Alzheimer's (AD) and Parkinson's Disease (PD), are becoming increasingly more common and are recognized as a social problem in modern societies. These disorders are characterized by a progressive neurodegeneration and are considered one of the main causes of disability and mortality worldwide. Currently, there is no existing cure for AD nor PD and the clinically used drugs aim only at symptomatic relief, and are not capable of stopping neurodegeneration. Over the last years, several drug candidates reached clinical trials phases, but they were suspended, mainly because of the unsatisfactory pharmacological benefits. Recently, the number of compounds developed using in silico approaches has been increasing at a promising rate, mainly evaluating the affinity for several macromolecular targets and applying filters to exclude compounds with potentially unfavorable pharmacokinetics. Thus, in this review, an overview of the current therapeutics in use for these two ND, the main targets in drug development, and the primary studies published in the last five years that used in silico approaches to design novel drug candidates for AD and PD treatment will be presented. In addition, future perspectives for the treatment of these ND will also be briefly discussed.pt
dc.language.isoengpt
dc.publisherMDPI AGpt
dc.relationDesign of new Catechol-O-methyltransferase inhibitors with therapeutic potential for diseases of the central nervous system—Project Centro-01-0145-FEDER- 000019—C4—Centro de Competências em Cloud Computingpt
dc.relationCICS-UBI: UIDB/00709/2020pt
dc.relationUCIBIO: UIDP/04378/2020pt
dc.relationUIDB/04378/2020pt
dc.relationSFRH/BSAB/150376/2019pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectneurodegenerative diseasespt
dc.subjectParkinson’s Diseasept
dc.subjectAlzheimer’s Diseasept
dc.subjectcomputer-aided drug designpt
dc.subjectin silico studiespt
dc.subject.meshAcetylcholinesterasept
dc.subject.meshAlzheimer Diseasept
dc.subject.meshAmyloid Precursor Protein Secretasespt
dc.subject.meshAntiparkinson Agentspt
dc.subject.meshAspartic Acid Endopeptidasespt
dc.subject.meshCatechol O-Methyltransferasept
dc.subject.meshCholinesterase Inhibitorspt
dc.subject.meshClinical Trials as Topicpt
dc.subject.meshComputer Simulationpt
dc.subject.meshDopamine Agentspt
dc.subject.meshDrug Designpt
dc.subject.meshExcitatory Amino Acid Antagonistspt
dc.subject.meshGPI-Linked Proteinspt
dc.subject.meshGene Expression Regulationpt
dc.subject.meshHumanspt
dc.subject.meshNeuroprotective Agentspt
dc.subject.meshParkinson Diseasept
dc.subject.meshReceptors, N-Methyl-D-Aspartatept
dc.subject.meshSirtuinspt
dc.titleRecent Developments in New Therapeutic Agents against Alzheimer and Parkinson Diseases: In-Silico Approachespt
dc.typearticle-
degois.publication.firstPage2193pt
degois.publication.issue8pt
degois.publication.titleMoleculespt
dc.peerreviewedyespt
dc.identifier.doi10.3390/molecules26082193pt
degois.publication.volume26pt
dc.date.embargo2021-04-11*
uc.date.periodoEmbargo0pt
item.fulltextCom Texto completo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.openairetypearticle-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0003-4297-5108-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
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