Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/104757
Título: | The Impact of Physical Exercise on the Circulating Levels of BDNF and NT 4/5: A Review | Autor: | Ribeiro, Daniel Petrigna, Luca Pereira, Frederico C. Muscella, Antonella Bianco, Antonino Tavares, Paula |
Palavras-chave: | exercise; neurotrophins; brain-derived neurotrophic factor; neurotrophin-4; peripheral circulation | Data: | 16-Ago-2021 | Editora: | MDPI | Título da revista, periódico, livro ou evento: | International Journal of Molecular Sciences | Volume: | 22 | Número: | 16 | Resumo: | (1) Background: One mechanism through which physical activity (PA) provides benefits is by triggering activity at a molecular level, where neurotrophins (NTs) are known to play an important role. However, the expression of the circulating levels of neurotrophic factors, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4/5), in response to exercise, is not fully understood. Therefore, the aim was to provide an updated overview on the neurotrophin (NT) variation levels of BDNF and NT-4/5 as a consequence of a long-term aerobic exercise intervention, and to understand and describe whether the upregulation of circulating NT levels is a result of neurotrophic factors produced and released from the brain, and/or from neurotrophic secreting peripheral organs. (2) Methods: The articles were collected from PubMed, SPORTDiscus, Web of Science, MEDLINE, and Embase. Data were analyzed through a narrative synthesis. (3) Results: 30 articles studied humans who performed training protocols that ranged from 4 to 48 weeks; 22 articles studied rodents with an intervention period that ranged from 4 to 64 weeks. (4) Conclusions: There is no unanimity between the upregulation of BDNF in humans; conversely, concerning both BDNF and NT-4/5 in animal models, the results are heterogeneous. Whilst BDNF upregulation appears to be in relative agreement, NT-4/5 seems to display contradictory and inconsistent conclusions. | URI: | https://hdl.handle.net/10316/104757 | ISSN: | 1422-0067 | DOI: | 10.3390/ijms22168814 | Direitos: | openAccess |
Aparece nas coleções: | FCDEF - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
The-impact-of-physical-exercise-on-the-circulating-levels-of-BDNF-and-NT-45-A-reviewInternational-Journal-of-Molecular-Sciences.pdf | 1.02 MB | Adobe PDF | Ver/Abrir |
Citações WEB OF SCIENCETM
8
Visto em 2/mai/2023
Visualizações de página
69
Visto em 7/mai/2024
Downloads
37
Visto em 7/mai/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons