Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/104757
DC Field | Value | Language |
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dc.contributor.author | Ribeiro, Daniel | - |
dc.contributor.author | Petrigna, Luca | - |
dc.contributor.author | Pereira, Frederico C. | - |
dc.contributor.author | Muscella, Antonella | - |
dc.contributor.author | Bianco, Antonino | - |
dc.contributor.author | Tavares, Paula | - |
dc.date.accessioned | 2023-01-24T12:36:11Z | - |
dc.date.available | 2023-01-24T12:36:11Z | - |
dc.date.issued | 2021-08-16 | - |
dc.identifier.issn | 1422-0067 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/104757 | - |
dc.description.abstract | (1) Background: One mechanism through which physical activity (PA) provides benefits is by triggering activity at a molecular level, where neurotrophins (NTs) are known to play an important role. However, the expression of the circulating levels of neurotrophic factors, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4/5), in response to exercise, is not fully understood. Therefore, the aim was to provide an updated overview on the neurotrophin (NT) variation levels of BDNF and NT-4/5 as a consequence of a long-term aerobic exercise intervention, and to understand and describe whether the upregulation of circulating NT levels is a result of neurotrophic factors produced and released from the brain, and/or from neurotrophic secreting peripheral organs. (2) Methods: The articles were collected from PubMed, SPORTDiscus, Web of Science, MEDLINE, and Embase. Data were analyzed through a narrative synthesis. (3) Results: 30 articles studied humans who performed training protocols that ranged from 4 to 48 weeks; 22 articles studied rodents with an intervention period that ranged from 4 to 64 weeks. (4) Conclusions: There is no unanimity between the upregulation of BDNF in humans; conversely, concerning both BDNF and NT-4/5 in animal models, the results are heterogeneous. Whilst BDNF upregulation appears to be in relative agreement, NT-4/5 seems to display contradictory and inconsistent conclusions. | pt |
dc.description.sponsorship | MOOD EXERsomes, POCI-01-0145-FEDER-030786; PTDC/SAU-DES/30786/2017), Strategic Projects (UID/NEU/04539/2013 and UID/NEU/04539/2019),), Strategic Project UIDB/04539/2020 and UIDP/04539/2020 (CIBB), COMPETE-FEDER (POCI-01-0145-FEDER-007440) and Centro 2020 Regional Operational Programmes (CENTRO-01-0145-FEDER-000012: HealthyAging2020 and CENTRO- 01-0145-FEDER- 000008: BrainHealth 2020) | - |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | exercise | pt |
dc.subject | neurotrophins | pt |
dc.subject | brain-derived neurotrophic factor | pt |
dc.subject | neurotrophin-4 | pt |
dc.subject | peripheral circulation | pt |
dc.subject.mesh | Brain-Derived Neurotrophic Factor | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Nerve Growth Factors | pt |
dc.subject.mesh | Reproducibility of Results | pt |
dc.subject.mesh | Up-Regulation | pt |
dc.subject.mesh | Exercise | pt |
dc.title | The Impact of Physical Exercise on the Circulating Levels of BDNF and NT 4/5: A Review | pt |
dc.type | article | - |
degois.publication.firstPage | 8814 | pt |
degois.publication.issue | 16 | pt |
degois.publication.title | International Journal of Molecular Sciences | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/ijms22168814 | pt |
degois.publication.volume | 22 | pt |
dc.date.embargo | 2021-08-16 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.orcid | 0000-0002-2287-2446 | - |
Appears in Collections: | FCDEF - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais |
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The-impact-of-physical-exercise-on-the-circulating-levels-of-BDNF-and-NT-45-A-reviewInternational-Journal-of-Molecular-Sciences.pdf | 1.02 MB | Adobe PDF | View/Open |
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