Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/104752
Título: | Nanobody-Based Theranostic Agents for HER2-Positive Breast Cancer: Radiolabeling Strategies | Autor: | Hrynchak, Ivanna Santos, Liliana Falcão, Amílcar Gomes, Célia M. Abrunhosa, Antero J. |
Palavras-chave: | nanobodies; targeted radionuclide therapy; HER2 breast cancer; radiolabeling strategies; nuclear imaging | Data: | 4-Out-2021 | Editora: | MDPI | Projeto: | FCT - PD/BDE/150331/2019 FCT - PD/BDE/150707/2020 |
Título da revista, periódico, livro ou evento: | International Journal of Molecular Sciences | Volume: | 22 | Número: | 19 | Resumo: | The overexpression of human epidermal growth factor 2 (HER2) in breast cancer (BC) has been associated with a more aggressive tumor subtype, poorer prognosis and shorter overall survival. In this context, the development of HER2-targeted radiotracers is crucial to provide a non-invasive assessment of HER2 expression to select patients for HER2-targeted therapies, monitor response and identify those who become resistant. Antibodies represent ideal candidates for this purpose, as they provide high contrast images for diagnosis and low toxicity in the therapeutic setting. Of those, nanobodies (Nb) are of particular interest considering their favorable kinetics, crossing of relevant biological membranes and intratumoral distribution. The purpose of this review is to highlight the unique characteristics and advantages of Nb-based radiotracers in BC imaging and therapy. Additionally, radiolabeling methods for Nb including direct labeling, indirect labeling via prosthetic group and indirect labeling via complexation will be discussed, reporting advantages and drawbacks. Furthermore, the preclinical to clinical translation of radiolabeled Nbs as promising theranostic agents will be reported. | URI: | https://hdl.handle.net/10316/104752 | ISSN: | 1422-0067 | DOI: | 10.3390/ijms221910745 | Direitos: | openAccess |
Aparece nas coleções: | I&D ICNAS - Artigos em Revistas Internacionais I&D CIBIT - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Nanobodybased-theranostic-agents-for-HER2positive-breast-cancer-Radiolabeling-strategiesInternational-Journal-of-Molecular-Sciences.pdf | 2.71 MB | Adobe PDF | Ver/Abrir |
Citações SCOPUSTM
16
Visto em 15/jul/2024
Citações WEB OF SCIENCETM
16
Visto em 2/jul/2024
Visualizações de página
92
Visto em 23/jul/2024
Downloads
123
Visto em 23/jul/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons