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https://hdl.handle.net/10316/103848
Título: | MENSAdb: a thorough structural analysis of membrane protein dimers | Autor: | Matos-Filipe, Pedro Preto, Antonio J. Koukos, Panagiotis I. Mourão, Joana Bonvin, Alexandre M. J. J. Moreira, Irina S. |
Data: | 5-Abr-2021 | Editora: | Oxford University Press | Projeto: | POCI-01-0145-FEDER-031356 PTDC/QUI-OUT/32243/2017 UIDB/04539/2020 |
Título da revista, periódico, livro ou evento: | Database | Volume: | 2021 | Resumo: | Membrane proteins (MPs) are key players in a variety of different cellular processes and constitute the target of around 60% of all Food and Drug Administration–approved drugs. Despite their importance, there is still a massive lack of relevant structural, biochemical and mechanistic information mainly due to their localization within the lipid bilayer. To help fulfil this gap, we developed the MEmbrane protein dimer Novel Structure Analyser database (MENSAdb). This interactive web application summarizes the evolutionary and physicochemical properties of dimeric MPs to expand the available knowledge on the fundamental principles underlying their formation. Currently, MENSAdb contains features of 167 unique MPs (63% homo- and 37% heterodimers) and brings insights into the conservation of residues, accessible solvent area descriptors, average B-factors, intermolecular contacts at 2.5 Å and 4.0 Å distance cut-offs, hydrophobic contacts, hydrogen bonds, salt bridges, π–π stacking, T-stacking and cation–π interactions. The regular update and organization of all these data into a unique platform will allow a broad community of researchers to collect and analyse a large number of features efficiently, thus facilitating their use in the development of prediction models associated with MPs. | URI: | https://hdl.handle.net/10316/103848 | ISSN: | 1758-0463 | DOI: | 10.1093/database/baab013 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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MENSAdb a thorough structural analysis of.pdf | 2.63 MB | Adobe PDF | Ver/Abrir |
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