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https://hdl.handle.net/10316/101507
Título: | Portal Pressure Impact on Clinical Outcome after Major Hepatectomy: A Systematic Review and Meta-Analysis | Autor: | Maciel Barbosa, Jorge Tralhão, José Guilherme Botelho, Maria Filomena Nunes Santos, Jorge Sousa-Pinto, Bernardo Abrantes, Ana Margarida Gomes Carrapita, Jorge Humberto |
Palavras-chave: | hepatobiliary surgery; liver; portal venous pressure; portal inflow modulation; posthepatectomy liver failure; meta-analysis | Data: | 2020 | Título da revista, periódico, livro ou evento: | Surgery, Gastroenterology and Oncology | Volume: | 25 | Número: | 3 | Resumo: | Aim of the study: To systematically review the evidence regarding the association between portal venous pressure (PVP) after hepatectomy and posthepatectomy liver failure (PLHF) or other postsurgical outcomes. Materials and methods: We searched PubMed, Scopus and Web of Science for studies assessing post-hepatectomy PVP (or its variation) and reporting its association with PHLF or other postsurgical outcomes. We performed a random-effects meta-analysis for the association between development of PHLF and post-hepatectomy PVP and its variation. Heterogeneity was assessed using Q-Cochran test and I2 statistic. Quality assessment was performed considering ROBINS-1 Cochrane tool. Results: Four studies, assessing 439 patients, met the eligibility criteria and were included in this systematic review. The meta-analyses, including 3 studies, demonstrated that patients developing PHLF did not have a significantly higher post-hepatectomy PVP when compared to the remainder (1.98; 95%CI=-1.44-5.39; p=0.256; I2=2%), but had a significantly higher PVP variation (increase) during hepatectomy (1.65; 95%CI=1.15-2.15; p<0.001; I2=0%). The quality of the studies allowed to consider the robustness of the conclusions as “median”. Conclusions: An increased PVP variation following hepatectomy associates with a higher risk of PHLF, but the same was not observed for the absolute value of post-hepatectomy PVP. | URI: | https://hdl.handle.net/10316/101507 | ISSN: | 2559-723X | DOI: | 10.21614/sgo-25-3-113 | Direitos: | openAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais |
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Portal-Pressure-Impact-on-Clinical-Outcome-after-Major-Hepatectomy-A-Systematic-Review-and-MetaAnalysisSurgery-Gastroenterology-and-Oncology.pdf | 1.14 MB | Adobe PDF | Ver/Abrir |
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