This research was funded by the PORTUGUESE FOUNDATION FOR SCIENCE AND TECHNOLOGY (FCT) and FEDER (FUNDO EUROPEU DE DESENVOLVIMENTO REGIONAL) through the COMPETE 2020, OPERATIONAL PROGRAMME FOR COMPETITIVENESS AND INTERNATIONALIZATION (POCI) (GenomePT: POCI-01-0145-FEDER-022184;WISDOM: POCI-01-0145-FEDER-029843); MEDISIS (CENTRO-01-0246-FEDER-000018); and project “Piloto para a elaboração de uma estratégia e uma rede regional para a medicina personalizada/precisão” Grant (CENTRO-08-5864-FSE-000039). The iBiMED research unit is supported by FCT (UID/BIM/04501/2020). S.F. and M.F. are directly supported by FCT grants (SFRH/BD/148323/2019 and SFRH/BD/131736/2017). A.R.S. is supported by an individual CEEC auxiliary research contract (CEECIND/00284/2018).

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This research was funded by the PORTUGUESE FOUNDATION FOR SCIENCE AND TECHNOLOGY (FCT) and FEDER (FUNDO EUROPEU DE DESENVOLVIMENTO REGIONAL) through the COMPETE 2020, OPERATIONAL PROGRAMME FOR COMPETITIVENESS AND INTERNATIONALIZATION (POCI) (GenomePT: POCI-01-0145-FEDER-022184;WISDOM: POCI-01-0145-FEDER-029843); MEDISIS (CENTRO-01-0246-FEDER-000018); and project “Piloto para a elaboração de uma estratégia e uma rede regional para a medicina personalizada/precisão” Grant (CENTRO-08-5864-FSE-000039). The iBiMED research unit is supported by FCT (UID/BIM/04501/2020). S.F. and M.F. are directly supported by FCT grants (SFRH/BD/148323/2019 and SFRH/BD/131736/2017). A.R.S. is supported by an individual CEEC auxiliary research contract (CEECIND/00284/2018).