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Title: HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer
Authors: Pádua, Diana
Pinto, Débora Filipa
Figueira, Paula
Pereira, Carlos Filipe 
Almeida, Raquel 
Mesquita, Patrícia
Keywords: Chemotherapy; Gastric cancer; HMGA1; Predictive value; Prognosis
Issue Date: 2021
Publisher: MDPI
Project: POCI-01-0145-FEDER-007274/Institute for Research and Innovation in Health Sciences 
POCI-01-0145-FEDER-029017/Cancer Research on Therapy Resistance: From Basic Mechanisms to Novel Targets 
Serial title, monograph or event: Current Oncology
Volume: 29
Issue: 1
Abstract: Gastric cancer is a serious health problem worldwide. Although its incidence is decreasing, the five-year survival rate remains low. Thus, it is essential to identify new biomarkers that could promote better diagnosis and treatment of patients with gastric cancer. High-mobility group AT-hook 1 (HMGA1) is a non-histone, chromatin-binding protein that has been found overexpressed in several tumor types. It has been correlated with invasion, metastasis, and drug resistance, leading to worse patient survival. The aim of this work was to evaluate the clinical value of HMGA1 in gastric cancer. HMGA1 expression was analyzed by immunohistochemistry in a single hospital series (n = 323) of gastric adenocarcinoma cases (stages I to IV) with clinicopathological and treatment data. In this series, HMGA1 expression showed no significant relevance as a prognostic biomarker. Nevertheless, a significantly better overall survival was observed in cases with high levels of HMGA1 when they were treated with chemotherapy, compared to the nontreated ones, implying that they can benefit more from treatment than patients with low expression of HMGA1. We thereby show for the first time that HMGA1 expression has a substantial value as a biomarker of response to chemotherapy in gastric cancer. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
ISSN: 1718-7729
DOI: 10.3390/curroncol29010005
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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