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https://hdl.handle.net/10316/96865
Title: | MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice | Authors: | Abellán-Álvaro, María Stork, Oliver Agustín-Pavón, Carmen Santos, Mónica |
Keywords: | Arginine-vasopressin; Corticotropin-releasing hormone; Maternal separation; Rett syndrome; c-FOS | Issue Date: | 11-Dec-2021 | Publisher: | BMC | Project: | PID2019-107322GB-C22 CENTRO-01-0145-FEDER-000008 |
Serial title, monograph or event: | Journal of Neurodevelopmental Disorders | Volume: | 13 | Issue: | 1 | Abstract: | Early-life stress can leave persistent epigenetic marks that may modulate vulnerability to psychiatric conditions later in life, including anxiety, depression and stress-related disorders. These are complex disorders with both environmental and genetic influences contributing to their etiology. Methyl-CpG Binding Protein 2 (MeCP2) has been attributed a key role in the control of neuronal activity-dependent gene expression and is a master regulator of experience-dependent epigenetic programming. Moreover, mutations in the MECP2 gene are the primary cause of Rett syndrome and, to a lesser extent, of a range of other major neurodevelopmental disorders. Here, we aim to study the interaction of MeCP2 with early-life stress in variables known to be affected by this environmental manipulation, namely anxiety-like behavior and activity of the underlying neural circuits. | URI: | https://hdl.handle.net/10316/96865 | ISSN: | 1866-1947 1866-1955 |
DOI: | 10.1186/s11689-021-09409-7 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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Journal of Neurodevelopmental Disorders _2021_ 13-59_Article_MeCP2HaplodeficiencyAndEarly-l.pdf | 4.31 MB | Adobe PDF | View/Open |
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