Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/95713
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dc.contributor.authorSoares, Sílvia-
dc.contributor.authorGuerreiro, Susana G-
dc.contributor.authorCruz-Martins, Natália-
dc.contributor.authorFaria, Isabel-
dc.contributor.authorBaylina, Pilar-
dc.contributor.authorSales, Maria Goreti-
dc.contributor.authorCorrea-Duarte, Miguel A-
dc.contributor.authorFernandes, Rúben-
dc.date.accessioned2021-09-09T14:30:23Z-
dc.date.available2021-09-09T14:30:23Z-
dc.date.issued2021-
dc.identifier.issn2234-943Xpt
dc.identifier.urihttp://hdl.handle.net/10316/95713-
dc.description.abstractIn the last years, extensive investigation on miRNomics have shown to have great advantages in cancer personalized medicine regarding diagnosis, treatment and even clinical outcomes. Prostate cancer (PCa) is the second most common male cancer and about 50% of all PCa patients received radiotherapy (RT), despite some of them develop radioresistance. Here, we aim to provide an overview on the mechanisms of miRNA biogenesis and to discuss the functional impact of miRNAs on PCa under radiation response. As main findings, 23 miRNAs were already identified as being involved in genetic regulation of PCa cell response to RT. The mechanisms of radioresistance are still poorly understood, despite it has been suggested that miRNAs play an important role in cell signaling pathways. Identification of miRNAs panel can be thus considered an upcoming and potentially useful strategy in PCa diagnosis, given that radioresistance biomarkers, in both prognosis and therapy still remains a challenge.pt
dc.language.isoengpt
dc.relationSFRH/BD/138271/2018pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectRNA therapy; microRNA; oncomiR; oncosupressor miR; prostate cancer; radiotherapypt
dc.titleThe Influence of miRNAs on Radiotherapy Treatment in Prostate Cancer - A Systematic Reviewpt
dc.typearticle-
degois.publication.firstPage704664pt
degois.publication.titleFrontiers in Oncologypt
dc.peerreviewedyespt
dc.identifier.doi10.3389/fonc.2021.704664pt
degois.publication.volume11pt
dc.date.embargo2021-01-01*
uc.date.periodoEmbargo0pt
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.orcid0000-0001-9936-7336-
Appears in Collections:FCTUC Eng.Química - Artigos em Revistas Internacionais
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This item is licensed under a Creative Commons License Creative Commons