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Title: Emerging Optical Materials in Sensing and Discovery of Bioactive Compounds
Authors: Vaz, Raquel 
Valpradinhos, Beatriz
Frasco, Manuela F.
Sales, Maria Goreti F. 
Keywords: Biosensors; Optical detection; Aquatic biotoxins; Drug discovery; Bioactive compounds
Issue Date: 2021
Publisher: MDPI
Project: PTDC/BTA-GES/32359/2017- POCI-01-0145-FEDER-032359/CY-SENSORS 
BD/09673/2020/PT/PhD grant 
Serial title, monograph or event: Sensors
Volume: 21
Issue: 17
Abstract: Optical biosensors are used in numerous applications and analytical fields. Advances in these sensor platforms offer high sensitivity, selectivity, miniaturization, and real-time analysis, among many other advantages. Research into bioactive natural products serves both to protect against potentially dangerous toxic compounds and to promote pharmacological innovation in drug discovery, as these compounds have unique chemical compositions that may be characterized by greater safety and efficacy. However, conventional methods for detecting these biomolecules have drawbacks, as they are time-consuming and expensive. As an alternative, optical biosensors offer a faster, simpler, and less expensive means of detecting various biomolecules of clinical interest. In this review, an overview of recent developments in optical biosensors for the detection and monitoring of aquatic biotoxins to prevent public health risks is first provided. In addition, the advantages and applicability of these biosensors in the field of drug discovery, including high-throughput screening, are discussed. The contribution of the investigated technological advances in the timely and sensitive detection of biotoxins while deciphering the pathways to discover bioactive compounds with great health-promoting prospects is envisaged to meet the increasing demands of healthcare systems
ISSN: 1424-8220
DOI: 10.3390/s21175784
Rights: openAccess
Appears in Collections:FCTUC Eng.Química - Artigos em Revistas Internacionais

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