Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/95088
Título: | Adiponectin involved in portal flow hepatic extraction of 13C-metacethin in obesity and non-alcoholic fatty liver | Autor: | Di Ciaula, Agostino Carbone, Federico Shanmugham, Harshitha Molina-Molina, Emilio Bonfrate, Leonilde Ministrini, Stefano Montecucco, Fabrizio Portincasa, Piero |
Palavras-chave: | Adiponectin; Breath test; Leptin; Liver function; Liver steatosis; Metabolic syndrome; Stable isotopes | Data: | 15-Jan-2021 | Projeto: | Marie Sklodowska-Curie Grant Agreement No. 722619. | Título da revista, periódico, livro ou evento: | European Journal of Internal Medicine | Resumo: | Obesity and non-alcoholic fatty liver disease (NAFLD) are high prevalence, inter-related conditions at increased risk for advanced liver diseases and related mortality. Adiponectin and leptin have divergent roles in the pathogenesis of fat accumulation and NAFLD. However, the relationships between body and liver fat accumulation, early modification of liver function and unbalanced adipokine levels are still scarcely explored. We studied by (13C)-methacetin breath test ((13C)-MBT) 67 adults stratified according to body mass index, and to presence/absence of ultrasonographic nonalcoholic fatty liver disease (uNAFLD). uNAFLD was detected in 20%, 73% and 96% of normal weight, overweight and obese subjects, respectively. The delta over baseline after 15 min (DOB15), a marker of hepatic extraction efficiency from portal blood flow, was lower in obese than in normal weight subjects, and in subjects with-, as compared to those without uNAFLD. The cumulative percent dose recovery after 30 min (cPDR30), a marker of liver microsomal function, was lower in uNAFLD patients. DOB15 was positively correlated with adiponectin levels in obese and in uNAFLD patients. uNAFLD patients also showed a positive correlation between cPDR30 values and adiponectin. Our data indicate the existence of early alterations of liver function in obese and in patients with uNAFLD. These dysfunctions are linked to altered leptin/adiponectin balance and can be identified noninvasively by (13C)-MBT. | URI: | https://hdl.handle.net/10316/95088 | ISSN: | 09536205 | DOI: | 10.1016/j.ejim.2021.03.036 | Direitos: | embargoedAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
adiponectin paper (Text) v.18 R1.pdf | 626.43 kB | Adobe PDF | Ver/Abrir |
Citações SCOPUSTM
12
Visto em 15/jul/2024
Citações WEB OF SCIENCETM
10
Visto em 2/jul/2024
Visualizações de página
103
Visto em 16/jul/2024
Downloads
169
Visto em 16/jul/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons