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https://hdl.handle.net/10316/93148
Title: | Synthesis of Novel Chiral Spiroisoxazolidine‐β‐Lactams from 6‐Alkylidenepenicillanates: A 1,3‐Dipolar Cycloaddition Approach | Authors: | Alves, Américo J. S. Melo, Teresa M. V. D. Pinho e |
Keywords: | Spiro‐β‐lactams; Isoxazolidines; Penicillanates; Nitrones; 1,3‐Dipolar cycloaddition | Issue Date: | 2020 | Publisher: | Wiley | Project: | info:eu-repo/grantAgreement/FCT/OE/SFRH/BD/128910/2017/PT/Novel spiro-lactams as new antimicrobial agents UIDB/00313/2020 UIDP/00313/2020 |
Serial title, monograph or event: | European Journal of Organic Chemistry | Volume: | 2020 | Issue: | 39 | Abstract: | The synthesis of a library of 6‐alkylidene‐β‐lactams, derived from 6‐aminopenicillanic acid is reported. The 1,3‐dipolar cycloaddition of these 6‐alkylidenepenicillanates with nitrones was explored as an approach to synthesize novel chiral spiroisoxazolidine‐β‐lactams. The reported methodology, which involves the generation of three new consecutive stereogenic centers, proved to be regio‐ and stereoselective, leading to novel chiral spiroisoxazolidine‐penicillanates efficiently. | URI: | https://hdl.handle.net/10316/93148 | ISSN: | 1434-193X 1099-0690 |
DOI: | 10.1002/ejoc.202001085 | Rights: | embargoedAccess |
Appears in Collections: | I&D CQC - Artigos em Revistas Internacionais |
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Alves2020EurJOC.pdf | 944.03 kB | Adobe PDF | View/Open |
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